| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TUB 1 |
| Specificity: |
This antibody reacts specifically with TUB 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TUB 1 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
(5) and Bardet-Biedl (6), A Gè, A candidate for the tub gene has been described (4), A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4), In addition to excessive deposition of adipose tissue, It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4), The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstré, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4), transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4), &Scaron, °, &ldquo, &permil, In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
rd5 |
| Also known as: |
TUB 1 Polyclonal Antibody |
| Other name: |
Anti-TUB 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TUB 1 |
| Short name: |
Anti-TUB 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-tubby homolog (mouse) 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
TUB and IDBG-30462 and ENSG00000166402 and 7275, TUB and IDBG-633715 and ENSBTAG00000004862 and 539051, Tub and IDBG-206024 and ENSMUSG00000031028 and 22141, nuclei, protein complex binding, rd5, this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006909 and pha this GO cytosis and biological process this GO :0007602 and phototransduction and biological process this GO :0007605 and sensory perception of sound and biological process this GO :0008020 and G-protein coupled photoreceptor activity and molecular function this GO :0009584 and detection of visible light and biological process this GO :0009725 and response to hormone and biological process this GO :0032403 and protein complex binding and molecular function this GO :0044259 and multicellular organismal macromolecule metabolic process and biological process this GO :0050766 and positive regulation of pha this GO cytosis and biological process this GO :0060041 and retina development in camera-type eye and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008020 : G-protein coupled photoreceptor activity and also this GO :0032403 : protein complex binding, this GO :0008020 : G-protein coupled photoreceptor activity, this GO :0032403 : protein complex binding, tubby homolog (mouse) |
| Identity: |
12406 |
| Gene: |
TUB |
More about : TUB |
| Long gene name: |
tubby bipartite transcription factor |
| Synonyms gene name: |
tubby (mouse) homolog tubby homolog (mouse) |
| Locus: |
11p15, 4 |
| Discovery year: |
1996-10-11 |
| GenBank acession: |
U54644 |
| Entrez gene record: |
7275 |
| Pubmed identfication: |
8612280 |
| RefSeq identity: |
NM_003320 |
| Havana BLAST/BLAT: |
OTTHUMG00000165690 |