| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
BBS8/TTC8 |
| Specificity: |
This antibody reacts specifically with BBS8/TTC8 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human BBS8 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
BBS is a heterogeneous disorder mapping to eight genetic loci and encoding eight proteins, BBS patients also have an increased risk of developing diabetes, BBS1-BBS8, BBS2 contains two overlapping genes: BBS2L1 and BBS2L2, BBS7 contains 672 amino acids and is expressed at low to moderate levels in most human tissues, BBSL1 was re-named BBS7, Five BBS proteins encode basal body or cilia proteins, and congenital heart defects, and developmental delay, hypertension, hypogenitalism, photoreceptor degeneration, polydactyly, renal abnormalities, suggesting that BBS is a ciliary dysfunction disorder, whereas BBS2L2 independently funcitons as BBS1, Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterized by obesity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
BBS8 RP51 |
| Also known as: |
BBS8/TTC8 Polyclonal Antibody |
| Other name: |
Anti-BBS8/TTC8 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
BBS8/TTC8 |
| Short name: |
Anti-BBS8/TTC8 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-BBS8/tetratricopeptide repeat domain 8 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Cytoplasm, TTC8 and IDBG-15274 and ENSG00000165533 and 123016, TTC8 and IDBG-646921 and ENSBTAG00000030432 and 615652, Ttc8 and IDBG-163183 and ENSMUSG00000021013 and 76260, protein binding, this GO :0001103 and RNA polymerase II repressing transcription factor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005813 and centrosome and cellular component this GO :0005929 and cilium and cellular component this GO :0007411 and axon guidance and biological process this GO :0007608 and sensory perception of smell and biological process this GO :0015031 and protein transport and biological process this GO :0021772 and olfactory bulb development and biological process this GO :0032391 and photoreceptor connecting cilium and cellular component this GO :0032880 and regulation of protein localization and biological process this GO :0034464 and BBSome and cellular component this GO :0035058 and nonmotile primary cilium assembly and biological process this GO :0035264 and multicellular organism growth and biological process this GO :0036064 and ciliary basal body and cellular component this GO :0042384 and cilium assembly and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0048560 and establishment of anatomical structure orientation and biological process this GO :0050893 and sensory processing and biological process this GO :0060170 and ciliary membrane and cellular component this GO :0060219 and camera-type eye photoreceptor cell differentiation and biological process this GO :0061326 and renal tubule development and biological process, this GO :0001103 : RNA polymerase II repressing transcription factor binding, this GO :0001103 : RNA polymerase II repressing transcription factor binding and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, tetratricopeptide repeat domain 8 |
| Identity: |
20087 |
| Gene: |
TTC8 |
More about : TTC8 |
| Long gene name: |
tetratricopeptide repeat domain 8 |
| Locus: |
14q31, 3 |
| Discovery year: |
2002-12-17 |
| GenBank acession: |
AK093891 |
| Entrez gene record: |
123016 |
| Pubmed identfication: |
14520415 20451172 |
| RefSeq identity: |
NM_144596 |
| Classification: |
Bardet-Biedl syndrome associated Tetratricopeptide repeat domain containing BBSome |
| Havana BLAST/BLAT: |
OTTHUMG00000170884 |