| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Torsin B |
| Specificity: |
This antibody reacts specifically with Torsin B |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Torsin B |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in the gene encoding TorsinB are associated with torsion dystonia, Expressed in a variety of tissues with particularly high levels in adult brain, TorsinB contains two PKC (protein kinase C) phosphorylations sites, TorsinB is thought to function as a molecular chaperone that assists in the conformational folding of membrane and secreted proteins, TorsinB plays a key role in postnatal developmental events and is essential for proper neurological development, Via its ability to regulate protein folding, a related family member, an autosomal dominant neurological disorder that is characterized by debilitating muscle contractions throughout the body, one ATP binding domain and several conserved cysteines and shares 69% amino acid identity with TorsinA, TorsinB is a 336 amino acid protein that localizes to the lumen of endoplasmic reticulum and belongs to the Torsin family |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DQ1 MGC4386 |
| Also known as: |
Torsin B Polyclonal Antibody |
| Other name: |
Anti-Torsin B Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Torsin B |
| Short name: |
Anti-Torsin B (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Torsin B (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
11995 |
| Gene: |
TOR1B |
More about : TOR1B |
| Long gene name: |
torsin family 1 member B |
| Synonyms gene name: |
member B (torsin B) , torsin family 1 |
| Synonyms name: |
torsin B |
| Locus: |
9q34, 11 |
| Discovery year: |
2000-02-17 |
| GenBank acession: |
AF007872 |
| Entrez gene record: |
27348 |
| Pubmed identfication: |
9288096 10644435 |
| RefSeq identity: |
NM_014506 |
| Havana BLAST/BLAT: |
OTTHUMG00000020795 |