| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
NGBR/Nogo B receptor |
| Specificity: |
This antibody reacts specifically with NGBR/Nogo B receptor |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human NGBR/Nogo B receptor |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
-B and -C, Knockdown of NgBR mRNA leads to decreased NPC2 levels, NgBR (Nogo-B receptor), NgBR also enhances Niemann-Pick type C2 protein (NPC2) stabilization, NgBR is involved in the regulation of vascular remodeling and angiogenesis, Nogo exists in three different splice forms, Nogo is expressed by oligodendrocytes but not by Schwann cells and associates primarily with the endoplasmic reticulum, Nogo-A, Through this interaction, also known as nuclear undecaprenyl pyrophosphate synthase 1 homolog, and inhibits the spreading of 3T3 fibroblasts, induces collapse of growth cones of chick dorsal root ganglion cells, is a 293 amino acid single-pass type I membrane protein that acts as a specific receptor for the amino-terminus of Nogo-B, which results in the hallmarks of NPC2 mutation: increased intracellular cholesterol accumulation and a loss of sterol sensing, Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MGC7199 NgBR TANGO14 |
| Also known as: |
NGBR/Nogo B receptor Polyclonal Antibody |
| Other name: |
Anti-NGBR/Nogo B receptor Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Description: |
2 or 3 and , However, In this sense, When such chemical-signals couple or bind to a receptor, a change in the electrical-activity of a cell, acetylcholine, am olfactory receptor is a protein-molecule that recognizes and responds to , an acetylcholine-receptor recognizes and responds to its endogenous-ligand, chemokinesor cytokines e, e, sometimes in pharmacology, such as enzymes, the term is also used to include other proteins that are drug-targets, they cause some form of cellular/tissue-response, transporters and ion-channels, The receptors are ligand binding factors of type 1, endogenous-chemical signals, g, g, protein-molecules , that receive chemical-signals from outside a cell |
| Gene target: |
NGBR/Nogo B receptor |
| Short name: |
Anti-NGBR/Nogo B receptor (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-NGBR/Nogo B receptor (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
21042 |
| Gene: |
NUS1 |
More about : NUS1 |
| Long gene name: |
NUS1 dehydrodolichyl diphosphate synthase subunit |
| Synonyms gene: |
C6orf68 |
| Synonyms gene name: |
cerevisiae) , chromosome 6 open reading frame 68 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S |
| Synonyms name: |
Nogo-B receptor transport and golgi organization 14 homolog (Drosophila) |
| Locus: |
6q22, 1 |
| Discovery year: |
2003-05-08 |
| GenBank acession: |
BC013026 |
| Entrez gene record: |
116150 |
| Pubmed identfication: |
25066056 |
| RefSeq identity: |
NM_138459 |
| Havana BLAST/BLAT: |
OTTHUMG00000015458 |