| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
AANAT Thr29 |
| Specificity: |
This antibody reacts specifically with AANAT (Thr29) |
| Modification: |
Phosphorylation |
| Modification site: |
Thr29 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from mouse AANAT around the phosphorylation site of Thr29 |
| Gene ID: |
11298 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Arylalkylamine N-acetyltransferase may contribute a multifactorial genetic diseases such as altered behavior in sleep/wake cycle, It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland, Melatonin is essential for seasonal reproduction, This enzyme is rapidly inactivated when animals are exposed to light at night, This protein is 80% identical to sheep and rat AA-NAT, and influences activity and sleep, modulates the function of the circadian clock in the suprachiasmatic nucleus, Arylalkylamine N-acetyltransferase belongs to the superfamily of acetyltransferases |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SNAT |
| Also known as: |
AANAT (Thr29) Polyclonal Antibody |
| Other name: |
Anti-AANAT (Thr29) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
AANAT (Thr29) |
| Short name: |
Anti-AANAT (Thr29) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-aralkylamine N-acetyltransferase (Thr29) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
14-3-3 protein binding, AANAT and IDBG-69711 and ENSG00000129673 and 15, Aanat and IDBG-214486 and ENSMUSG00000020804 and 11298, Cytoplasm, DSPS and SNAT, this GO :0004059 and aralkylamine N-acetyltransferase activity and molecular function this GO :0004060 and arylamine N-acetyltransferase activity and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006474 and N-terminal protein amino acid acetylation and biological process this GO :0007623 and circadian rhythm and biological process this GO :0008080 and N-acetyltransferase activity and molecular function this GO :0009416 and response to light stimulus and biological process this GO :0010043 and response to zinc ion and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0030187 and melatonin biosynthetic process and biological process this GO :0032868 and response to insulin and biological process this GO :0034097 and response to cytokine and biological process this GO :0034641 and cellular nitrogen compound metabolic process and biological process this GO :0034695 and response to prostaglandin E and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0046219 and indolalkylamine biosynthetic process and biological process this GO :0046688 and response to copper ion and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051412 and response to corticosterone and biological process this GO :0051591 and response to cAMP and biological process this GO :0051592 and response to calcium ion and biological process this GO :0071320 and cellular response to cAMP and biological process this GO :0071889 and 14-3-3 protein binding and molecular function, this GO :0004059 : aralkylamine N-acetyltransferase activity, this GO :0004059 : aralkylamine N-acetyltransferase activity and also this GO :0004060 : arylamine N-acetyltransferase activity and also this GO :0008080 : N-acetyltransferase activity and also this GO :0071889 : 14-3-3 protein binding, this GO :0004060 : arylamine N-acetyltransferase activity, this GO :0008080 : N-acetyltransferase activity, this GO :0071889 : 14-3-3 protein binding, aralkylamine N-acetyltransferase |
| Identity: |
19 |
| Gene: |
AANAT |
More about : AANAT |
| Long gene name: |
aralkylamine N-acetyltransferase |
| Synonyms gene name: |
arylalkylamine N-acetyltransferase |
| Synonyms name: |
serotonin N-acetyltransferase |
| Locus: |
17q25, 1 |
| Discovery year: |
1995-12-13 |
| GenBank acession: |
U40347 |
| Entrez gene record: |
15 |
| Pubmed identfication: |
8661026 |
| RefSeq identity: |
NM_001088 |
| Classification: |
GCN5 related N-acetyltransferases |
| Havana BLAST/BLAT: |
OTTHUMG00000180179 |