| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HSD17B8 |
| Specificity: |
This antibody reacts specifically with HSD17B8 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HSD17B8 |
| Gene ID: |
7923 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
17beta-HSD8 converts active steroids to their inactive form through its oxidative activity, 17beta-HSD8 is predominantly expressed in placenta, It has also been suggested that low levels of 17beta-HSD proteins may result in an underdeveloped urogenital system, It has been proposed that a reduction in the levels of 17beta-HSD8 may lead to abnormal elevations in the local level of sex steroids, It is a key player in the inactivation of Estradiol and Testosterone, and pancreas, endometrium and prostate but can also be found in liver, ovary and kidney, which can lead to recessive renal cystic disease, with lowest levels found in testis, 17beta-HSD8 belongs to the 17beta-HSD family of proteins that regulate the availability of steroids within a tissue |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HKE6 D6S2245E RING2 KE6 H2-KE6 SDR30C1 |
| Also known as: |
HSD17B8 Polyclonal Antibody |
| Other name: |
Anti-HSD17B8 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HSD17B8 |
| Short name: |
Anti-HSD17B8 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-HSD17B8 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3554 |
| Gene: |
HSD17B8 |
More about : HSD17B8 |
| Long gene name: |
hydroxysteroid 17-beta dehydrogenase 8 |
| Synonyms gene: |
FABGL |
| Synonyms gene name: |
E coli) like (E, FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, coli) hydroxysteroid (17-beta) dehydrogenase 8 |
| Synonyms name: |
member 1 , short chain dehydrogenase/reductase family 30C |
| Locus: |
6p21, 32 |
| Discovery year: |
2000-06-26 |
| GenBank acession: |
D82061 |
| Entrez gene record: |
7923 |
| Pubmed identfication: |
8812499 19027726 |
| RefSeq identity: |
NM_014234 |
| Classification: |
Short chain dehydrogenase/reductase superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000031117 |