| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MAGI1/IRSP58 |
| Specificity: |
This antibody reacts specifically with MAGI1/IRSP58 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MAGI1 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
MAGI-1, MAGI-1a and MAGI-1b, MAGI-1c, MAGI-2 and MAGI-3 (membrane associated guanylate kinase inverted-1 and 2), MAGI-2 and MAGI-3 are localized to the plasma membrane, The closely related MAGUK proteins, The third isoform, The transcripts of MAGI-1 are alternatively spliced to produce three distinct proteins having unique C-terminals, Three protein-protein interaction modules characteristically define MAGUK related proteins: the PDZ domain, Two variants, and it is primarily expressed in the liver and kidney, and they contribute to protein scaffolding by associating with the protein phosphatase PTEN, are associated with the membrane and cytosolic fractions and are primarily expressed in the brain, encodes for a nuclear localization signal that localizes MAGI-1c to the nucleus, however, likewise contain the GuK domain and five PDZ domains, the SH3 domain and the guanylate kinase (GuK) domain, the SH3 domain is replaced with a WW domain, The membrane-associated guanylate kinase (MAGUK) proteins are concentrated at the membrane-cytoskeletal interface where they facilitate the assembly of multiprotein complexes on the inner surface of the plasma membrane |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FLJ31349 |
| Also known as: |
MAGI1/IRSP58 Polyclonal Antibody |
| Other name: |
Anti-MAGI1/IRSP58 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MAGI1/IRSP58 |
| Short name: |
Anti-MAGI1/IRSP58 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, WW and PDZ domain containing 1/IRSP58 (polyclonal), antibody to-membrane associated guanylate kinase |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
AIP-3 and AIP3 and BAIAP1 and BAP-1 and BAP1 and MAGI-1 and Magi1d and TNRC19 and WWP3, MAGI1 and IDBG-43316 and ENSG00000151276 and 9223, MAGI1 and IDBG-645100 and ENSBTAG00000010581 and 783484, Magi1 and IDBG-171358 and ENSMUSG00000045095 and 14924, WW and PDZ domain containing 1, alpha-actinin binding, nuclei, this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0005923 and tight junction and cellular component this GO :0006461 and protein complex assembly and biological process this GO :0007155 and cell adhesion and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0030054 and cell junction and cellular component this GO :0042995 and cell projection and cellular component this GO :0051393 and alpha-actinin binding and molecular function this GO :0070997 and neuron death and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0051393 : alpha-actinin binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0051393 : alpha-actinin binding, membrane associated guanylate kinase |
| Identity: |
23034 |
| Gene: |
CNKSR3 |
More about : CNKSR3 |
| Long gene name: |
CNKSR family member 3 |
| Synonyms gene: |
MAGI1 |
| Synonyms gene name: |
membrane associated guanylate kinase interacting protein-like 1 |
| Locus: |
6q25, 2 |
| Discovery year: |
2003-11-26 |
| GenBank acession: |
AK055911 |
| Entrez gene record: |
154043 |
| RefSeq identity: |
NM_173515 |
| Classification: |
Sterile alpha motif domain containing PDZ domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000015873 |