| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PIST/GOPC |
| Specificity: |
This antibody reacts specifically with PIST/GOPC |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PIST |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Additionally, CAL or FIG, Chromosomal aberrations in the gene encoding PIST are found in glioblastoma multiform (GBM), Expressed ubiquitously and containing one PDZ (DHR) domain, PIST functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation, PIST is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy, Three isoforms of PIST exist due to alternative splicing events, a common and aggressive form of brain tumor, also known as GOPC (golgi associated PDZ and coiled-coil motif containing), as well as to the membrane of the golgi apparatus and to the cell junction, is a 462 amino acid protein that localizes to the cytoplasm, suggesting a role for mutated PIST in carcinogenesis, PIST (PDZ protein interacting specifically with TC10) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
dJ94G16, 2 PIST FIG GOPC1 CAL |
| Also known as: |
PIST/GOPC Polyclonal Antibody |
| Other name: |
Anti-PIST/GOPC Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PIST/GOPC |
| Short name: |
Anti-PIST/GOPC (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PIST/GOPC (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
17643 |
| Gene: |
GOPC |
More about : GOPC |
| Long gene name: |
golgi associated PDZ and coiled-coil motif containing |
| Locus: |
6q22, 1 |
| Discovery year: |
2003-08-29 |
| GenBank acession: |
AF287894 |
| Entrez gene record: |
57120 |
| Pubmed identfication: |
11162552 11520064 |
| RefSeq identity: |
NM_020399 |
| Classification: |
PDZ domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000015457 |