| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SorLA |
| Specificity: |
This antibody reacts specifically with SorLA |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SorLA |
| Gene ID: |
79845 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Endogenous sorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function, It can also bind to RAP, It is expressed mainly in brain (cerebral cortex, SorLA, SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase, SorLa is a multifunctional endocytis receptor important in lipoprotein and protease uptake, The N-terminal propeptide, a single transmembrane receptor, also known as Sorting protein-related receptor containing LDLR class A (SorLA), binds LDL (the main cholesterol-carrying lipoprotein of plasma) and transports it into cells by endocytosis, but can also be found in liver, can be cleaved by furin or homologous proteases, cerebellum and the occipital pole), is a Type I membrane protein that may be involved in cell-cell interaction, kidney, receptor-associated protein, spinal cord, testis and pancreas, which is removed, Sortilin-related receptor |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
gp250 LR11 LRP9 SorLA SorLA-1 |
| Also known as: |
SorLA Polyclonal Antibody |
| Other name: |
Anti-SorLA Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SorLA |
| Short name: |
Anti-SorLA (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SorLA (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
11185 |
| Gene: |
SORL1 |
More about : SORL1 |
| Long gene name: |
sortilin related receptor 1 |
| Synonyms gene: |
C11orf32 |
| Synonyms gene name: |
L(DLR class) A repeats-containing , chromosome 11 open reading frame 32 sortilin-related receptor |
| Synonyms name: |
LDLR relative with 11 ligand-binding repeats |
| Locus: |
11q24, 1 |
| Discovery year: |
1996-12-27 |
| GenBank acession: |
Y08110 |
| Entrez gene record: |
6653 |
| Pubmed identfication: |
9157966 8940146 |
| RefSeq identity: |
NM_003105 |
| Classification: |
Fibronectin type III domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000166057 |