| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SPRR3/Cornin B |
| Specificity: |
This antibody reacts specifically with SPRR3/Cornifin B |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SPRR3/Cornifin B |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Contrastly, Due to its highly inducible nature, Esophagin is considered a marker of squamous differentiation, Esophagin is typically not expressed in healthy human epithelium, Esophagin serves as a cross-linking protein within the cornified cell envelope and may play a role in the maintenance of normal esophageal epithelial homeostasis, It is expressed in mucosal epithelia such as esophagus and tongue and is strongly induced during epidermal keratinocyte differentiation, It shares significant homology with the related proteins, SPRR1 and SPRR2, also known as small proline-rich protein 3 (SPR3) or Cornifin â, belongs to the cornifin family of cornified-envelope structural proteins, but its expression is upregulated in numerous hyperproliferative disorders of the skin, its expression is dramatically downregulated in esophageal squamous cell carcinoma, &circ, «, Esophagin |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
SPRR3/Cornifin B Polyclonal Antibody |
| Other name: |
Anti-SPRR3/Cornifin B Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SPRR3/Cornifin B |
| Short name: |
Anti-SPRR3/Cornifin B (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SPRR3/Cornifin B (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
11268 |
| Gene: |
SPRR3 |
More about : SPRR3 |
| Long gene name: |
small proline rich protein 3 |
| Synonyms gene name: |
small proline-rich protein 3 |
| Locus: |
1q21, 3 |
| Discovery year: |
1993-01-20 |
| GenBank acession: |
AY118269 |
| Entrez gene record: |
6707 |
| Pubmed identfication: |
8325635 |
| RefSeq identity: |
NM_005416 |
| Classification: |
Small proline rich proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000013872 |