| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PCDH8 |
| Specificity: |
This antibody reacts specifically with PCDH8 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PCDH8 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Localized to the cell membrane and expressed specifically in fetal and adult brain, PCDH8 (protocadherin-8), PCDH8 is inactivated or silenced in breast cancer, PCDH8 is thought to play a role in cell adhesion events in the central nervous system (CNS), There are three protocadherin gene clusters, Two isoforms of PCDH8 that differ in their cytoplasmic tails are expressed due to alternative splicing events, all of which contain multiple tandemly arranged genes, also known as Arcadlin or PAPC, beta and gamma, designated alpha, is a 1, suggesting a possible role in tumor suppression, 070 amino acid single-pass type I membrane protein that contains six cadherin domains and belongs to the protocadherin family, Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PAPC ARCADLIN |
| Also known as: |
PCDH8 Polyclonal Antibody |
| Other name: |
Anti-PCDH8 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PCDH8 |
| Short name: |
Anti-PCDH8 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-protocadherin 8 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ARCADLIN and PAPC, Cell surfaces, PCDH8 and IDBG-36060 and ENSG00000136099 and 5100, PCDH8 and IDBG-628623 and ENSBTAG00000018179 and 513346, Pcdh8 and IDBG-183100 and ENSMUSG00000036422 and 18530, calcium ion binding, this GO :0001756 and somitogenesis and biological process this GO :0005509 and calcium ion binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007156 and homophilic cell adhesion and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0007268 and synaptic transmission and biological process this GO :0016020 and membrane and cellular component this GO :0016331 and morphogenesis of embryonic epithelium and biological process this GO :0030054 and cell junction and cellular component this GO :0030425 and dendrite and cellular component this GO :0042734 and presynaptic membrane and cellular component this GO :0045211 and postsynaptic membrane and cellular component, this GO :0005509 : calcium ion binding, this GO :0005509 : calcium ion binding, protocadherin 8 |
| Identity: |
8660 |
| Gene: |
PCDH8 |
More about : PCDH8 |
| Long gene name: |
protocadherin 8 |
| Locus: |
13q14, 3 |
| Discovery year: |
1998-04-21 |
| GenBank acession: |
AF061573 |
| Entrez gene record: |
5100 |
| Pubmed identfication: |
9787079 9315676 |
| RefSeq identity: |
NM_002590 |
| Classification: |
Non-clustered protocadherins |
| Havana BLAST/BLAT: |
OTTHUMG00000016979 |