| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
NLGN1/NLGN2 |
| Specificity: |
This antibody reacts specifically with NLGN1/NLGN2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human NLGN1/NLGN2 |
| Gene ID: |
1131 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Members of the neuroligin family include Neuroligin 1, Neuroexin 1b binds to the EF-hand domain of Neuroligin 1 and requires calcium ion, Neuroligin 2 and Neuroligin 3, Neuroligins also bind to PSD-95, Neuroligins are expressed in excitatory neuronal synaptic clefts, Neuroligins play a role in the formation and remodeling of CNS synapses by binding to b-neurexins, a family of neuronal cell surface proteins, a large esterase homology domain, a short cytoplasmic domain, a single transmembrane region, and an EF-hand binding domain (1, which may recruit ion channels and neurotransmitter receptors to the synapses, 2), Neuroligins are a family of plasma membrane proteins that possess an N-terminal hydrophobic domain |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA1070 |
| Also known as: |
NLGN1/NLGN2 Polyclonal Antibody |
| Other name: |
Anti-NLGN1/NLGN2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
NLGN1/NLGN2 |
| Short name: |
Anti-NLGN1/NLGN2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-neuroligin 1/neuroligin 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Cell surfaces, Cell surfaces, GABAergic and biological process this GO :0032433 and filopodium tip and cellular component this GO :0035418 and protein localization to synapse and biological process this GO :0042043 and neurexin family protein binding and molecular function this GO :0045184 and establishment of protein localization and biological process this GO :0045202 and synapse and cellular component this GO :0045211 and postsynaptic membrane and cellular component this GO :0045664 and regulation of neuron differentiation and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0048789 and cytoskeletal matrix organization at active zone and biological process this GO :0050804 and regulation of synaptic transmission and biological process this GO :0050808 and synapse organization and biological process this GO :0050839 and cell adhesion molecule binding and molecular function this GO :0051260 and protein homooli this GO merization and biological process this GO :0051290 and protein heterotetramerization and biological process this GO :0051491 and positive regulation of filopodium assembly and biological process this GO :0051965 and positive regulation of synapse assembly and biological process this GO :0051968 and positive regulation of synaptic transmission, GABAergic and biological process this GO :0035418 and protein localization to synapse and biological process this GO :0035641 and locomotory exploration behavior and biological process this GO :0042043 and neurexin family protein binding and molecular function this GO :0042734 and presynaptic membrane and cellular component this GO :0045202 and synapse and cellular component this GO :0045211 and postsynaptic membrane and cellular component this GO :0045217 and cell-cell junction maintenance and biological process this GO :0050804 and regulation of synaptic transmission and biological process this GO :0050808 and synapse organization and biological process this GO :0050839 and cell adhesion molecule binding and molecular function this GO :0050885 and neuromuscular process controlling balance and biological process this GO :0051965 and positive regulation of synapse assembly and biological process this GO :0051968 and positive regulation of synaptic transmission, NL1, NLGN1 and IDBG-636117 and ENSBTAG00000031891 and 530042, NLGN1 and IDBG-65853 and ENSG00000169760 and 22871, NLGN2 and IDBG-24850 and ENSG00000169992 and 57555, NLGN2 and IDBG-634885 and ENSBTAG00000020252 and 787986, Nlgn1 and IDBG-133960 and ENSMUSG00000063887 and 192167, Nlgn2 and IDBG-192156 and ENSMUSG00000051790 and 216856, cell adhesion molecule binding, cell adhesion molecule binding, glutamatergic and biological process this GO :0060077 and inhibitory synapse and cellular component this GO :0072553 and terminal button organization and biological process this GO :0097104 and postsynaptic membrane assembly and biological process this GO :0097105 and presynaptic membrane assembly and biological process this GO :0097116 and gephyrin clustering and biological process this GO :0097119 and postsynaptic density protein 95 clustering and biological process this GO :0097151 and positive regulation of inhibitory postsynaptic membrane potential and biological process this GO :2000311 and regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity and biological process this GO :2000463 and positive regulation of excitatory postsynaptic membrane potential and biological process, glutamatergic and biological process this GO :0060999 and positive regulation of dendritic spine development and biological process this GO :0072553 and terminal button organization and biological process this GO :0097091 and synaptic vesicle clustering and biological process this GO :0097104 and postsynaptic membrane assembly and biological process this GO :0097105 and presynaptic membrane assembly and biological process this GO :0097113 and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering and biological process this GO :0097114 and N-methyl-D-aspartate receptor clustering and biological process this GO :0097115 and neurexin clustering and biological process this GO :0097119 and postsynaptic density protein 95 clustering and biological process this GO :0097120 and receptor localization to synapse and biological process this GO :0097481 and neuronal postsynaptic density and cellular component this GO :1900029 and positive regulation of ruffle assembly and biological process this GO :1900244 and positive regulation of synaptic vesicle endocytosis and biological process this GO :1902533 and positive regulation of intracellular signal transduction and biological process this GO :2000302 and positive regulation of synaptic vesicle exocytosis and biological process this GO :2000310 and regulation of N-methyl-D-aspartate selective glutamate receptor activity and biological process this GO :2000311 and regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity and biological process this GO :2000463 and positive regulation of excitatory postsynaptic membrane potential and biological process, neuroligin 1, this GO :0002087 and regulation of respiratory gaseous exchange by neurological system process and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006605 and protein targeting and biological process this GO :0007157 and heterophilic cell-cell adhesion and biological process this GO :0007158 and neuron cell-cell adhesion and biological process this GO :0007399 and nervous system development and biological process this GO :0007416 and synapse assembly and biological process this GO :0008152 and metabolic process and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0016080 and synaptic vesicle targeting and biological process this GO :0016339 and calcium-dependent cell-cell adhesion and biological process this GO :0016787 and hydrolase activity and molecular function this GO :0017146 and N-methyl-D-aspartate selective glutamate receptor complex and cellular component this GO :0023041 and neuronal signal transduction and biological process this GO :0030054 and cell junction and cellular component this GO :0030165 and PDZ domain binding and molecular function this GO :0030425 and dendrite and cellular component this GO :0032230 and positive regulation of synaptic transmission, this GO :0002087 and regulation of respiratory gaseous exchange by neurological system process and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007158 and neuron cell-cell adhesion and biological process this GO :0007416 and synapse assembly and biological process this GO :0008152 and metabolic process and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0016787 and hydrolase activity and molecular function this GO :0019233 and sensory perception of pain and biological process this GO :0030054 and cell junction and cellular component this GO :0032230 and positive regulation of synaptic transmission, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0005515 : protein binding and also this GO :0016787 : hydrolase activity and also this GO :0030165 : PDZ domain binding and also this GO :0042043 : neurexin family protein binding and also this GO :0046983 : protein dimerization activity and also this GO :0050839 : cell adhesion molecule binding, this GO :0004872 : receptor activity and also this GO :0005515 : protein binding and also this GO :0016787 : hydrolase activity and also this GO :0042043 : neurexin family protein binding and also this GO :0050839 : cell adhesion molecule binding, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0016787 : hydrolase activity, this GO :0016787 : hydrolase activity, this GO :0030165 : PDZ domain binding, this GO :0042043 : neurexin family protein binding, this GO :0042043 : neurexin family protein binding, this GO :0046983 : protein dimerization activity, this GO :0050839 : cell adhesion molecule binding, this GO :0050839 : cell adhesion molecule binding, neuroligin 2 |
| Identity: |
14291 |
| Gene: |
NLGN1 |
More about : NLGN1 |
| Long gene name: |
neuroligin 1 |
| Locus: |
3q26, 31 |
| Discovery year: |
2001-01-02 |
| GenBank acession: |
AB028993 |
| Entrez gene record: |
22871 |
| Pubmed identfication: |
10767552 10819331 |
| RefSeq identity: |
NM_014932 |
| Havana BLAST/BLAT: |
OTTHUMG00000157005 |