| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Junctophilin 3 |
| Specificity: |
This antibody reacts specifically with Junctophilin 3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Junctophilin 3 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
-2 and -3, Junctophilin-1 is predominantly expressed in skeletal muscle, Junctophilin-2 is expressed in heart and skeletal muscle, Junctophilin-3 is expressed in brain, Junctophilins contain a cytoplasmic domain which binds to the plasma membrane, Mutant mice lacking the Jph2 gene exhibit embryonic lethality and possess cardiac myocytes that express abnormal calcium transients, The JPH3 alternatively spliced exon 2A has been suggested as a site for CTG repeat expansion leading to a Huntington disease-like autosomal dominant disorder, The three subtypes in this family are Junctophilin-1, as well as an ER/SR membrane spanning hydrophobic C-terminal segment, but is also expressed at low levels in heart, Junctophilins are components of the junctional complexes between plasma membranes and endoplasmic or sarcoplasmic reticulums present in all excitable cells |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
JP-3 CAGL237 HDL2 JP3 |
| Also known as: |
Junctophilin 3 Polyclonal Antibody |
| Other name: |
Anti-Junctophilin 3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Junctophilin 3 |
| Short name: |
Anti-Junctophilin 3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Junctophilin 3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
14203 |
| Gene: |
JPH3 |
More about : JPH3 |
| Long gene name: |
junctophilin 3 |
| Synonyms gene: |
TNRC22 |
| Synonyms gene name: |
trinucleotide repeat containing 22 |
| Locus: |
16q24, 2 |
| Discovery year: |
2000-12-08 |
| GenBank acession: |
AB042636 |
| Entrez gene record: |
57338 |
| Pubmed identfication: |
10949023 10891348 |
| Classification: |
Trinucleotide repeat containing |
| Havana BLAST/BLAT: |
OTTHUMG00000137656 |