| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Keratocan |
| Specificity: |
This antibody reacts specifically with Keratocan |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Keratocan |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Biglycan, Defects in the gene encoding for Keratocan can cause cornea plana 2 (CNA2), Fibromod-ulin, Fibromodulin is a collagen-binding keratan sulphate proteoglycan that influences adhesion processes of connective tissue and plays a role in fibrillogenesis by regulating collagen fibril spacing and thickness, Keratocan, Keratocan (KTN) develops corneal transparency and maintains the stromal matrix structure, Keratocan is a secreted protein in the extracellular matrix that binds to keratan sulfate chains, Keratocan is mainly detected in the cornea, Lumican and Osteoglycin mediate extracellular matrix organization and are binding partners of TGF Beta, The Decorin core protein binds to growth factors, an autosomal recessive disorder where the forward convex curvature of the cornea is flattened, and to the Decorin endocytosis receptor, but can also be expressed in trachea, intercellular matrix molecules such as Fibronectin and Throm-bospondin, intestine, lung and skeletal muscle, ovary, Small leucine-rich proteoglycans (SLRPs) such as Decorin |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SLRR2B |
| Also known as: |
Keratocan Polyclonal Antibody |
| Other name: |
Anti-Keratocan Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Keratocan |
| Short name: |
Anti-Keratocan (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Keratocan (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
6309 |
| Gene: |
KERA |
More about : KERA |
| Long gene name: |
keratocan |
| Synonyms gene: |
CNA2 |
| Synonyms name: |
keratocan proteoglycan |
| Locus: |
12q21, 33 |
| Discovery year: |
1999-08-26 |
| GenBank acession: |
AF063301 |
| Entrez gene record: |
11081 |
| Pubmed identfication: |
10565548 10802664 |
| RefSeq identity: |
NM_007035 |
| Classification: |
Small leucine rich repeat proteoglycans |
| Havana BLAST/BLAT: |
OTTHUMG00000170073 |
| Locus Specific Databases: |
LRG_538 |