| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
AFAP1L2 |
| Specificity: |
This antibody reacts specifically with AFAP1L2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human AFAP1L2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
AFAP-110 contains additional protein-binding domains as well, AFAP-110 provides a platform for the preparation of larger signaling complexes, AFAP-1L2 (Actin filament-associated protein 1-like 2), AFAP-1L2 interacts with Src kinase and may play a role in Src-regulated transcription activation, AFAP-1L2 is expressed in thyroid and spleen and can also be detected at lower levels in lung, By linking signaling molecules to actin filaments, Like its relative AFAP110, There are four isoforms of AFAP-1L2 that are produced as a result of alternative splicing events, activates Src kinases in response to cellular signals and also directly affects Actin organization as an Actin filament cross-linking protein, also known as XB130, and serves as an adaptor protein, brain, is a 818 amino acid cytoplasmic protein that contains two Pleckstrin homology (PH) domains, pancreas and kidney, which are normally found in proteins involved in intracellular signaling, Actin filament associated protein (AFAP-110) interacts directly with actin filaments through its C-terminal actin-binding domain |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FLJ14564 Em:AC005383, 4 XB130 |
| Also known as: |
AFAP1L2 Polyclonal Antibody |
| Other name: |
Anti-AFAP1L2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
AFAP1L2 |
| Short name: |
Anti-AFAP1L2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-actin filament associated protein 1-like 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
AFAP1L2 and IDBG-640002 and ENSBTAG00000004895 and 615436, AFAP1L2 and IDBG-90372 and ENSG00000169129 and 84632, Afap1l2 and IDBG-179434 and ENSMUSG00000025083 and 226250, Cytoplasm, DNA-templated and biological process this GO :0061098 and positive regulation of protein tyrosine kinase activity and biological process, SH2 domain binding, this GO :0005737 and cytoplasm and cellular component this GO :0006954 and inflammatory response and biological process this GO :0007346 and regulation of mitotic cell cycle and biological process this GO :0017124 and SH3 domain binding and molecular function this GO :0030296 and protein tyrosine kinase activator activity and molecular function this GO :0032675 and regulation of interleukin-6 production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0045742 and positive regulation of epidermal growth factor receptor signaling pathway and biological process this GO :0045893 and positive regulation of transcription, this GO :0017124 : SH3 domain binding, this GO :0017124 : SH3 domain binding and also this GO :0030296 : protein tyrosine kinase activator activity and also this GO :0042169 : SH2 domain binding, this GO :0030296 : protein tyrosine kinase activator activity, this GO :0042169 : SH2 domain binding, actin filament associated protein 1-like 2 |
| Identity: |
25901 |
| Gene: |
AFAP1L2 |
More about : AFAP1L2 |
| Long gene name: |
actin filament associated protein 1 like 2 |
| Synonyms gene: |
KIAA1914 |
| Synonyms gene name: |
KIAA1914 actin filament associated protein 1-like 2 |
| Locus: |
10q25, 3 |
| Discovery year: |
2004-02-18 |
| GenBank acession: |
BC024314 |
| Entrez gene record: |
84632 |
| Pubmed identfication: |
11572484 17412687 |
| RefSeq identity: |
NM_032550 |
| Classification: |
Pleckstrin homology domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000019086 |