| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SKP2 |
| Specificity: |
This antibody reacts specifically with SKP2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Skp2 |
| Gene ID: |
6502 |
| Swiss Prot: |
Q13309 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CDK9, CDT1, Degradation of CDKN1B/p27kip also requires CKS1, Degradation of TAL1 also requires STUB1, FOXO1, KMT2A/MLL1, Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, RAG2, RBL2, Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2, Recognizes target proteins ORC1, Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition, TOB1 and TAL1, UBP43, and probably MYC, signal transduction and transcription, thereby regulating cell migration, Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FBXL1 FBL1 p45 |
| Also known as: |
SKP2 Polyclonal Antibody |
| Other name: |
Anti-SKP2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SKP2 |
| Short name: |
Anti-SKP2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SKP2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
10901 |
| Gene: |
SKP2 |
More about : SKP2 |
| Long gene name: |
S-phase kinase associated protein 2 |
| Synonyms gene name: |
E3 ubiquitin protein ligase , S-phase kinase-associated protein 2 (p45) S-phase kinase-associated protein 2 |
| Locus: |
5p13, 2 |
| Discovery year: |
1995-12-18 |
| GenBank acession: |
U33761 |
| Entrez gene record: |
6502 |
| Pubmed identfication: |
8646875 |
| RefSeq identity: |
NM_005983 |
| Classification: |
F-box and leucine rich repeat proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000131106 |