| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PRX |
| Specificity: |
This antibody reacts specifically with Periaxin |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from mousePRX/Periaxin |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
DlgA (Drosophila disc large tumor suppressor), Jul 2008]Seems to be required for maintenance of peripheral nerve myelin sheath, May have a role in axon-glial interactions, May have a role in the early phases of myelin deposition, Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell, [provided by RefSeq, and ZO1 (a mammalian tight junction protein), possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane, type 4F and Dejerine-Sottas neuropathy, This gene encodes a protein involved in peripheral nerve myelin upkeep |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA1620 |
| Also known as: |
Periaxin Polyclonal Antibody |
| Other name: |
Anti-Periaxin Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Periaxin |
| Short name: |
Anti-Periaxin (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Periaxin (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
13797 |
| Gene: |
PRX |
More about : PRX |
| Long gene name: |
periaxin |
| Locus: |
19q13, 2 |
| Discovery year: |
2001-02-15 |
| GenBank acession: |
AB046840 |
| Entrez gene record: |
57716 |
| Pubmed identfication: |
10839370 9143514 |
| RefSeq identity: |
NM_020956 |
| Classification: |
PDZ domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000182597 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_265 |