| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Ron Tyr1238+Tyr1239 |
| Specificity: |
This antibody reacts specifically with Ron (Tyr1238+Tyr1239) |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr1238+Tyr1239 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cell membrane |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human MST1R around the phosphorylation site of Tyr1238+Tyr1239 |
| Gene ID: |
4486 |
| Swiss Prot: |
Q04912 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Alternatively, Following activation by ligand, Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules, PI3 kinase-AKT, PLCG1 or the adapter GAB1, Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand, RON signaling activates the wound healing response by promoting epithelial cell migration, Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, Regulates many physiological processes including cell survival, interacts with the PI3-kinase subunit PIK3R1, migration and differentiation, or PLCgamma-PKC, proliferation as well as survival at the wound site, Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CD136, CDw136, MSP receptor, MST1R, Macrophage-stimulating protein receptor, PTK8, Protein-tyrosine kinase 8, p185-Ron, RON |
| Also known as: |
Ron (Tyr1238+Tyr1239) Antibody |
| Other name: |
Anti-Ron (Tyr1238+Tyr1239) |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Ron (Tyr1238+Tyr1239) |
| Short name: |
Anti-Ron (Tyr1238+Tyr1239) Fluor 594 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Ron (Tyr1238+Tyr1239) |