| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PNP / Purine Nucleoside Phosphorylase |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, Immunohistochemistry (FFPE): 1-2ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the Purine nucleoside phosphorylase antibody should be determined by the researcher |
| Added buffer: |
025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2 |
| Intented use: |
This antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P00491 |
| Purity: |
Antigen affinity |
| Description: |
Genetic deficiencies of PNP result in severely compromised T?lymphocyte function and neurologic dysfunction, It is presented results from gene dosage studies consistent with assignment of the PNP locus to band 14q13, PNP is expressed in most tissues, an enzyme that catalyzes the reversible phosphorolysis of the purine nucleosides and deoxynucleosides inosine, and deoxyguanosine, deoxyinosine, guanosine, with markedly greater expression in lymphoid tissues, The PNP gene encodes Purine nucleoside phosphorylase |
| Immunogen: |
Amino acids 161-189 (AMSDAYDRTMRQRALSTWKQMGEQRELQE-human) were used as the immunogen for the Purine nucleoside phosphorylase antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Purine nucleoside phosphorylase antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
Cytoplasmic |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PNP / Purine Nucleoside Phosphorylase |
| Short name: |
PNP Antibody / Purine Nucleoside Phosphorylase |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
purine nucleoside phosphorylase (Antibody to) / Purine Nucleoside Phosphorylase |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cytoplasm, NP and PRO1837 and PUNP, PNP and IDBG-2272 and ENSG00000198805 and 4860, phosphate ion binding, this GO :0001882 and nucleoside binding and molecular function this GO :0002060 and purine nucleobase binding and molecular function this GO :0003824 and catalytic activity and molecular function this GO :0004731 and purine-nucleoside phosphorylase activity and molecular function this GO :0005622 and intracellular and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006139 and nucleobase-containing compound metabolic process and biological process this GO :0006144 and purine nucleobase metabolic process and biological process this GO :0006148 and inosine catabolic process and biological process this GO :0006195 and purine nucleotide catabolic process and biological process this GO :0006738 and nicotinamide riboside catabolic process and biological process this GO :0006955 and immune response and biological process this GO :0008144 and drug binding and molecular function this GO :0009116 and nucleoside metabolic process and biological process this GO :0034356 and NAD biosynthesis via nicotinamide riboside salvage pathway and biological process this GO :0034418 and urate biosynthetic process and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042301 and phosphate ion binding and molecular function this GO :0042493 and response to drug and biological process this GO :0043101 and purine-containing compound salvage and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0046638 and positive regulation of alpha-beta T cell differentiation and biological process this GO :0055086 and nucleobase-containing small molecule metabolic process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070970 and interleukin-2 secretion and biological process, this GO :0001882 : nucleoside binding, this GO :0001882 : nucleoside binding and also this GO :0002060 : purine nucleobase binding and also this GO :0003824 : catalytic activity and also this GO :0004731 : purine-nucleoside phosphorylase activity and also this GO :0008144 : drug binding and also this GO :0042301 : phosphate ion binding, this GO :0002060 : purine nucleobase binding, this GO :0003824 : catalytic activity, this GO :0004731 : purine-nucleoside phosphorylase activity, this GO :0008144 : drug binding, this GO :0042301 : phosphate ion binding, purine nucleoside phosphorylase |
| Identity: |
9327 |
| Gene: |
PPY |
More about : PPY |
| Long gene name: |
pancreatic polypeptide |
| Synonyms: |
PNP |
| Synonyms name: |
pancreatic polypeptide Y prepro-PP (prepropancreatic polypeptide) |
| Locus: |
17q21, 31 |
| Discovery year: |
1986-01-01 |
| Entrez gene record: |
5539 |
| Pubmed identfication: |
3753985 |
| RefSeq identity: |
NM_002722 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000181800 |