| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Kisspeptin |
| Specificity: |
Kisspeptin, This antibody detects Kisspeptin-10 region of Kisspeptin |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Kiss-1 |
| Gene ID: |
3814 |
| Swiss Prot: |
Q15726 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Activation of the receptor inhibits cell proliferation and cell migration, Generates a C-terminally amidated peptide, Kp-1, Kp-1 is a decapeptide derived from the primary translation product, Kp-1 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself, May regulate events downstream of cell-matrix adhesion, The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood, The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts, isolated in conditioned medium of first trimester trophoblast, key characteristics of tumor metastasis, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54, perhaps involving cytoskeletal reorganization, Metastasis suppressor protein in malignant melanomas and in some breast cancers |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
Kisspeptin Polyclonal Antibody |
| Other name: |
Anti-Kisspeptin Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Kisspeptin |
| Short name: |
Anti-Kisspeptin (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Kisspeptin (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
6341 |
| Gene: |
KISS1 |
More about : KISS1 |
| Long gene name: |
KiSS-1 metastasis-suppressor |
| Synonyms name: |
prepro-kisspeptin kisspeptin |
| Locus: |
1q32, 1 |
| Discovery year: |
1998-05-18 |
| GenBank acession: |
U43527 |
| Entrez gene record: |
3814 |
| Pubmed identfication: |
9192814 9806840 |
| RefSeq identity: |
NM_002256 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000036060 |