| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Calcium Sensing Receptor / CASR |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (FFPE): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the Calcium Sensing Receptor antibody should be determined by the researcher |
| Intented use: |
This Calcium Sensing Receptor antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P41180 |
| Purity: |
Antigen affinity |
| Description: |
It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, Mutations in this gene cause familial hypocalciuric hypercalcemia, and neonatal severe primary hyperparathyroidism, and the cells lining the kidney tubule, familial, isolated hypoparathyroidism, thus this protein plays an essential role in maintaining mineral ion homeostasis, The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland |
| Immunogen: |
Amino acids Q926-S1078 of the human protein were used as the immunogen for the Calcium Sensing Receptor antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Calcium Sensing Receptor antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
membranous, Cytoplasmic |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Calcium Sensing Receptor / CASR |
| Short name: |
Calcium Sensing Receptor Antibody / CASR |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Calcium Sensing Receptor (Antibody to) / CASR |
| Alternative technique: |
antibodies |
| Identity: |
1514 |
| Gene: |
CASR |
More about : CASR |
| Long gene name: |
calcium sensing receptor |
| Synonyms gene: |
HHC HHC1 |
| Synonyms gene name: |
hypocalciuric hypercalcemia 1 calcium-sensing receptor |
| Synonyms: |
FHH NSHPT GPRC2A |
| Synonyms name: |
severe neonatal hyperparathyroidism |
| Locus: |
3q21, 1 |
| Discovery year: |
1992-12-04 |
| GenBank acession: |
U20760 |
| Entrez gene record: |
846 |
| Pubmed identfication: |
7677761 |
| RefSeq identity: |
NM_000388 |
| Classification: |
Calcium sensing receptors |
| Locus Specific Databases: |
CASRdb Calcium Sensing Receptor Locus Mutation Database |