| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Neuropilin 1 |
| Specificity: |
This antibody reacts specifically with Neuropilin-1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human neuropilin-1 |
| Gene ID: |
8829 |
| Swiss Prot: |
O14786 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis, It binds to semaphorin 3A, It may also induce apoptosis by sequestering VEGF-165, It may regulate VEGF-induced angiogenesis, It mediates the chemorepulsant activity of semaphorins, Its expression has an averse effect on blood vessel number and integrity, May bind as well various members of the semaphorin family, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B, The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system, The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
BDCA4, CD304, NRP, NRP1, Neuropilin-1, VEGF165R, Vascular endothelial cell growth factor 165 receptor, NP1 |
| Also known as: |
Neuropilin-1 Polyclonal Antibody |
| Other name: |
Anti- Neuropilin-1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Neuropilin-1 |
| Short name: |
Anti- Neuropilin-1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, Antibody to Neuropilin-1 (polyclonal) |
| Alternative technique: |
polyclonals |