| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
XIAP |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the XIAP antibody should be determined by the researcher |
| Intented use: |
This XIAP antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P98170 |
| Purity: |
Antigen affinity |
| Description: |
Alternate splicing results in multiple transcript variants, It is mapped to chromosome Xq25, Members of this family share a conserved motif termed, Mutations in this gene are the cause of X-linked lymphoproliferative syndrome, This gene encodes a protein that belongs to a family of apoptotic suppressor proteins, This protein also inhibits at least two members of the caspase family of cell-death proteases, This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, also known as IAP3 or BIRC4, and interleukin 1-beta converting enzyme, baculovirus IAP repeat, caspase-3 and caspase-7, is a protein that stops apoptotic cell death, which is necessary for their anti-apoptotic function, XIAP |
| Immunogen: |
Amino acids A15-V244 were used as the immunogen for the XIAP antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the XIAP antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
XIAP |
| Short name: |
XIAP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
X-linked inhibitor on apoptosis (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
XIAP and IDBG-85142 and ENSG00000101966 and 331, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, nuclei, this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0016055 and Wnt signaling pathway and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0030510 and regulation of BMP signaling pathway and biological process this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0043027 and cysteine-type endopeptidase inhibitor activity involved in apoptotic process and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043154 and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045088 and regulation of innate immune response and biological process this GO :0050727 and regulation of inflammatory response and biological process this GO :0055070 and copper ion homeostasis and biological process this GO :0070424 and regulation of nucleotide-binding oli this GO merization domain containing signaling pathway and biological process this GO :0090263 and positive regulation of canonical Wnt signaling pathway and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :1902530 and positive regulation of protein linear polyubiquitination and biological process, this GO :0004842 : ubiquitin-protein transferase activity, this GO :0004842 : ubiquitin-protein transferase activity and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0016874 : ligase activity and also this GO :0043027 : cysteine-type endopeptidase inhibitor activity involved in apoptotic process, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0016874 : ligase activity, this GO :0043027 : cysteine-type endopeptidase inhibitor activity involved in apoptotic process, X-linked inhibitor of apoptosis |
| Identity: |
592 |
| Gene: |
XIAP |
More about : XIAP |
| Long gene name: |
X-linked inhibitor of apoptosis |
| Synonyms gene: |
API3 BIRC4 |
| Synonyms gene name: |
E3 ubiquitin protein ligase , baculoviral IAP repeat-containing 4 X-linked inhibitor of apoptosis |
| Synonyms: |
hILP |
| Locus: |
Xq25 |
| Discovery year: |
1998-06-10 |
| GenBank acession: |
U45880 |
| Entrez gene record: |
331 |
| Pubmed identfication: |
8552191 8654366 15749826 |
| RefSeq identity: |
NM_001167 |
| Classification: |
Baculoviral IAP repeat containing |
| Havana BLAST/BLAT: |
OTTHUMG00000022336 |
| Locus Specific Databases: |
BIRC4base: Mutation registry for X-linked lymphoproliferative syndrome Mental Retardation database LRG_19 |