| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Tau protein |
| Specificity: |
This antibody reacts specifically with Tau protein |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cell membrane, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Tau protein |
| Gene ID: |
4137 |
| Swiss Prot: |
P10636 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome, The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization, and might be involved in the establishment and maintenance of neuronal polarity, suggesting that tau functions as a linker protein between both, Promotes microtubule assembly and stability |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MTBT1 tau PPND FTDP-17 TAU MSTD MTBT2 FLJ31424 MGC138549 PPP1R103 MAPT |
| Also known as: |
Tau protein Polyclonal Antibody |
| Other name: |
Anti-Tau protein Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Tau protein |
| Short name: |
Anti-Tau protein (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Taurine protein (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
2729 |
| Gene: |
DDPAC |
More about : DDPAC |
| Long gene name: |
microtubule associated protein tau |
| Synonyms gene: |
MAPTL |
| Synonyms name: |
G protein beta1/gamma2 subunit-interacting factor 1 microtubule-associated protein tau, isoform 4 protein phosphatase 1, regulatory subunit 103 |
| Locus: |
17q21, 31 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
J03778 |
| Entrez gene record: |
4137 |
| Pubmed identfication: |
7936241 3131773 |
| RefSeq identity: |
NM_016835 |
| Classification: |
Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000168833 |
| Locus Specific Databases: |
Alzheimer Disease &, Frontotemporal Dementia Mutation Database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_660 |