| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MMP2 |
| Specificity: |
This antibody reacts specifically with MMP2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
MAT conjugated synthetic peptide derived from human MMP2 |
| Gene ID: |
4313 |
| Swiss Prot: |
P08253 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also cleaves KISS at a Gly-|-Leu bond, Appears to have a role in myocardial cell death pathways, As well as degrading extracellular matrix proteins, Cleaves GSK3beta in vitro, Contributes to myocardial oxidative stress by regulating the activity of GSK3beta, Involved in the formation of the fibrovascular tissues in association with MMP14, Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, Ligand for integrinv/beta3 on the surface of blood vessels, NFAT and IRF transcriptional pathways, PEX, and atherosclerotic plaque rupture, angiogenesis, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction, inflammation, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin, the C-terminal non-catalytic fragment of MMP2, tissue repair, tumor invasion, Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TBE-1 |
| Also known as: |
MMP2 Polyclonal Antibody |
| Other name: |
Anti-MMP2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MMP2 |
| Short name: |
Anti-MMP2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-MMP2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
7166 |
| Gene: |
MMP2 |
More about : MMP2 |
| Long gene name: |
matrix metallopeptidase 2 |
| Synonyms gene: |
CLG4 CLG4A |
| Synonyms gene name: |
72kDa gelatinase, 72kDa type IV collagenase) , matrix metalloproteinase 2 (gelatinase A |
| Locus: |
16q12, 2 |
| Discovery year: |
1989-05-25 |
| Entrez gene record: |
4313 |
| Classification: |
Matrix metallopeptidases |
| Havana BLAST/BLAT: |
OTTHUMG00000133202 |