| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TAB1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the TAB1 antibody should be determined by the researcher |
| Intented use: |
This TAB1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q15750 |
| Purity: |
Antigen affinity |
| Description: |
It is mapped to 22q13, TAB1 also can activate the kinase activity of TAK1 by direct interaction, TAB1 plays an important role in skin homeostasis, The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, This protein can interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), What's more, also called TAB1, and it may be an important signaling intermediate between TGFB receptors and TAK1, and oncogenesis, and thus represents an alternative activation pathway, in addition to the MAPKK pathways, is an enzyme that in humans is encoded by the MAP3K7IP1 gene, which contributes to the biological responses of MAPK14 to various stimuli, which is known to mediate various intracellular signaling pathways, wound repair, 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 |
| Immunogen: |
Amino acids NFVAQRLSAELLLGQLNAEHAEADVRRVLLQ of human TAB1 were used as the immunogen for the TAB1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TAB1 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TAB1 |
| Short name: |
TAB1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TGF-beta activated kinase 1/MAP3K7 binding protein 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
3\'-Tab1 and MAP3K7IP1, MAP3K7IP1 and IDBG-641725 and ENSBTAG00000019828 and 519958, TAB1 and IDBG-8281 and ENSG00000100324 and 10454, Tab1 and IDBG-163423 and ENSMUSG00000022414 and 66513, leucine rich repeat containing receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0043234 and protein complex and cellular component this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0048273 and mitogen-activated protein kinase p38 binding and molecular function this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0070423 and nucleotide-binding oli this GO merization domain containing signaling pathway and biological process, mitogen-activated protein kinase p38 binding, nuclei, this GO :0000185 and activation of MAPKKK activity and biological process this GO :0000187 and activation of MAPK activity and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0003007 and heart morphogenesis and biological process this GO :0003824 and catalytic activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0007254 and JNK cascade and biological process this GO :0008047 and enzyme activator activity and molecular function this GO :0010008 and endosome membrane and cellular component this GO :0019209 and kinase activator activity and molecular function this GO :0030324 and lung development and biological process this GO :0032403 and protein complex binding and molecular function this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035872 and nucleotide-binding domain, this GO :0003824 : catalytic activity, this GO :0003824 : catalytic activity and also this GO :0005515 : protein binding and also this GO :0008047 : enzyme activator activity and also this GO :0019209 : kinase activator activity and also this GO :0032403 : protein complex binding and also this GO :0048273 : mitogen-activated protein kinase p38 binding, this GO :0005515 : protein binding, this GO :0008047 : enzyme activator activity, this GO :0019209 : kinase activator activity, this GO :0032403 : protein complex binding, this GO :0048273 : mitogen-activated protein kinase p38 binding, TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| Identity: |
18157 |
| Gene: |
TAB1 |
More about : TAB1 |
| Long gene name: |
TGF-beta activated kinase 1 (MAP3K7) binding protein 1 |
| Synonyms gene: |
MAP3K7IP1 |
| Synonyms gene name: |
mitogen-activated protein kinase kinase kinase 7 interacting protein 1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| Synonyms name: |
TAK1-binding protein 1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 |
| Locus: |
22q13, 1 |
| Discovery year: |
2002-02-22 |
| GenBank acession: |
U49928 |
| Entrez gene record: |
10454 |
| Pubmed identfication: |
8638164 10187861 |
| RefSeq identity: |
NM_153497 |
| Havana BLAST/BLAT: |
OTTHUMG00000151102 |