| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CXCR3 |
| Specificity: |
This antibody is specific for isoform 2: CXCR3BCXCR3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CXCR3 |
| Gene ID: |
2833 |
| Swiss Prot: |
P49682 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Binds to CCL21, CXCL10 and CXCL11 and mediates the proliferation, CXCL10 and CXCL11 on the proliferation, Does not promote cell chemotaxis respons, Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis, Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, Isoform 3: Mediates the activity of CXCL11, Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis, Probably promotes cell chemotaxis response, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716), survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716), Isoform 1: Receptor for the C-X-C chemokine CXCL9 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CKR-L2 CMKAR3 IP10-R MigR CD183 |
| Also known as: |
CXCR3 Polyclonal Antibody |
| Other name: |
Anti-CXCR3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CXCR3 |
| Short name: |
Anti-CXCR3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-chemokine (C-X-C motif) receptor 3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
C-X-C chemokine binding, CD182 and CD183 and CKR-L2 and CMKAR3 and GPR9 and IP10-R and Mig-R and MigR, CXCR3 and IDBG-635748 and ENSBTAG00000014798 and 497018, CXCR3 and IDBG-76333 and ENSG00000186810 and 2833, Cell surfaces, Cxcr3 and IDBG-164788 and ENSMUSG00000050232 and 12766, this GO :0001525 and angiogenesis and biological process this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0002685 and regulation of leukocyte migration and biological process this GO :0004872 and receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004950 and chemokine receptor activity and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006928 and cellular component movement and biological process this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0007155 and cell adhesion and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010818 and T cell chemotaxis and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016494 and C-X-C chemokine receptor activity and molecular function this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0019722 and calcium-mediated signaling and biological process this GO :0019956 and chemokine binding and molecular function this GO :0019958 and C-X-C chemokine binding and molecular function this GO :0030816 and positive regulation of cAMP metabolic process and biological process this GO :0043950 and positive regulation of cAMP-mediated signaling and biological process this GO :0045087 and innate immune response and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050921 and positive regulation of chemotaxis and biological process this GO :0051281 and positive regulation of release of sequestered calcium ion into cytosol and biological process this GO :0071954 and chemokine (C-C motif) ligand 11 production and biological process this GO :1900118 and negative regulation of execution phase of apoptosis and biological process this GO :1900119 and positive regulation of execution phase of apoptosis and biological process, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0004950 : chemokine receptor activity and also this GO :0016494 : C-X-C chemokine receptor activity and also this GO :0019956 : chemokine binding and also this GO :0019958 : C-X-C chemokine binding, this GO :0004930 : G-protein coupled receptor activity, this GO :0004950 : chemokine receptor activity, this GO :0016494 : C-X-C chemokine receptor activity, this GO :0019956 : chemokine binding, this GO :0019958 : C-X-C chemokine binding, chemokine (C-X-C motif) receptor 3 |
| Identity: |
4540 |
| Gene: |
CXCR3 |
More about : CXCR3 |
| Long gene name: |
C-X-C motif chemokine receptor 3 |
| Synonyms gene: |
GPR9 |
| Synonyms gene name: |
G protein-coupled receptor 9 chemokine (C-X-C motif) receptor 3 |
| Locus: |
Xq13, 1 |
| Discovery year: |
1994-11-01 |
| GenBank acession: |
U32674 |
| Entrez gene record: |
2833 |
| Pubmed identfication: |
8666380 9064356 |
| Classification: |
CD molecules C-X-C motif chemokine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000033326 |