| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
cIAP2 / BIRC3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the cIAP2 antibody should be determined by the researcher |
| Intented use: |
This cIAP2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13489 |
| Purity: |
Antigen affinity |
| Description: |
It contains 3 baculovirus IAP repeats and a ring finger domain, The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, Transcript variants encoding the same isoform have been identified, a potent inducer of free radicals, cIAP2 is a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases, Baculoviral IAP repeat-containing protein 3 (also known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene |
| Immunogen: |
Amino acids 1-191 of human cIAP2 were used as the immunogen for the cIAP2 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the cIAP2 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
cIAP2 / BIRC3 |
| Short name: |
cIAP2 Antibody / BIRC3 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
cIAP2 (Antibody to) / baculoviral IAP repeat containing 3 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AIP1 and API2 and c-IAP2 and CIAP2 and HAIP1 and HIAP1 and MALT2 and MIHC and RNF49, BIRC3 and IDBG-629168 and ENSBTAG00000024918 and 514386, BIRC3 and IDBG-69045 and ENSG00000023445 and 330, Birc3 and IDBG-133177 and ENSMUSG00000032000 and 11796, ligase activity, nuclei, this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007283 and spermatogenesis and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0016567 and protein ubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0034121 and regulation of toll-like receptor signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038061 and NIK/NF-kappaB signaling and biological process this GO :0039535 and regulation of RIG-I signaling pathway and biological process this GO :0042326 and negative regulation of phosphorylation and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0045087 and innate immune response and biological process this GO :0045088 and regulation of innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0050727 and regulation of inflammatory response and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0060544 and regulation of necroptotic process and biological process this GO :0060546 and negative regulation of necroptotic process and biological process this GO :0070266 and necroptotic process and biological process this GO :0070424 and regulation of nucleotide-binding oli this GO merization domain containing signaling pathway and biological process this GO :2000116 and regulation of cysteine-type endopeptidase activity and biological process this GO :2000378 and negative regulation of reactive oxygen species metabolic process and biological process, this GO :0004842 : ubiquitin-protein transferase activity, this GO :0004842 : ubiquitin-protein transferase activity and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0016874 : ligase activity, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0016874 : ligase activity, baculoviral IAP repeat containing 3 |
| Identity: |
591 |
| Gene: |
BIRC3 |
More about : BIRC3 |
| Long gene name: |
baculoviral IAP repeat containing 3 |
| Synonyms gene: |
API2 |
| Synonyms gene name: |
baculoviral IAP repeat-containing 3 |
| Synonyms: |
cIAP2 hiap-1 MIHC RNF49 MALT2 c-IAP2 |
| Synonyms name: |
apoptosis inhibitor 2 TNFR2-TRAF signaling complex protein mammalian IAP homolog C inhibitor of apoptosis protein 1 |
| Locus: |
11q22, 2 |
| Discovery year: |
1998-06-10 |
| GenBank acession: |
L49432 |
| Entrez gene record: |
330 |
| Pubmed identfication: |
8552191 8548810 |
| RefSeq identity: |
NM_001165 |
| Classification: |
Baculoviral IAP repeat containing Ring finger proteins Caspase recruitment domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000167324 |