| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
EWS / EWSR1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the EWSR1 antibody should be determined by the researcher |
| Intented use: |
This EWSR1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q01844 |
| Purity: |
Antigen affinity |
| Description: |
Alternative splicing of this gene results in multiple transcript variants, Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis, Mutations in this gene, Related pseudogenes have been identified on chromosomes 1 and 14, The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain, These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein, and RNA processing and transport, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors, cell signaling, including gene expression, specifically a t(11, 22)(q24, This gene encodes a multifunctional protein that is involved in various cellular processes, q12) translocation |
| Immunogen: |
Amino acids NDSVTLDDLADFFKQCGVVKMNKRTGQPMIH of human EWSR1 were used as the immunogen for the EWSR1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the EWSR1 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
Nuclear |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
EWS / EWSR1 |
| Short name: |
EWS Antibody / EWSR1 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
EWS (Antibody to) / EWSR1 |
| Alternative technique: |
antibodies |
| Identity: |
3508 |
| Gene: |
EWSR1 |
More about : EWSR1 |
| Long gene name: |
EWS RNA binding protein 1 |
| Synonyms gene name: |
Ewing sarcoma breakpoint region 1 |
| Synonyms: |
EWS |
| Locus: |
22q12, 2 |
| Discovery year: |
1992-11-27 |
| Entrez gene record: |
2130 |
| Pubmed identfication: |
1522903 |
| RefSeq identity: |
NM_005243 |
| Classification: |
Zinc fingers RANBP2-type RNA binding motif containing |
| Havana BLAST/BLAT: |
OTTHUMG00000151107 |