| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Aquaporin 4 / AQP4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-F, IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5-1ug/ml, 5ug/ml, IHC (Frozen): 0, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the AQP4 antibody should be determined by the researcher |
| Intented use: |
This AQP4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P55087 |
| Purity: |
Antigen affinity |
| Description: |
0, AQP4 is expressed in astrocytes and is upregulated by direct insult to the central nervous system, And AQP4 is the predominant water channel in the brain and has an important role in brain water homeostasis, It is abundant in mammalian brain and is concentrated in astrocytic foot processes at the blood-brain barrier, M1 and the subsequent 10 amino acids are encoded by exon 0, Similar to other aquaporins, The gene of AQP4 is mapped to 18q11, Unlike other aquaporins, When spliced together, an alternative coding initiation sequence (designated exon 0) was located 2, and 5, and 92 amino acids separated by introns of 0, the AQP4 gene is composed of 4 exons encoding 127, the next 11 amino acids and M23 are encoded by exon 1, 1, 2 kb, 2-q12, 3, 7 kb upstream of exon 1, 8, 27, 55, Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells |
| Immunogen: |
Amino acids KPGVVHVIDVDRGEEKKGKDQSGEVLSSV of human Aquaporin 4 were used as the immunogen for the AQP4 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the AQP4 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Aquaporin 4 / AQP4 |
| Short name: |
Aquaporin 4 Antibody / AQP4 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Aquaporin 4 (Antibody to) / aquaporin 4 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AQP4 and IDBG-1836 and ENSG00000171885 and 361, AQP4 and IDBG-643803 and ENSBTAG00000019037 and 281008, Aqp4 and IDBG-129483 and ENSMUSG00000024411 and 11829, Cell surfaces, HMIWC2 and MIWC, porin activity, this GO :0005215 and transporter activity and molecular function this GO :0005372 and water transmembrane transporter activity and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0006810 and transport and biological process this GO :0006833 and water transport and biological process this GO :0007399 and nervous system development and biological process this GO :0007565 and female pregnancy and biological process this GO :0007588 and excretion and biological process this GO :0007605 and sensory perception of sound and biological process this GO :0009314 and response to radiation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0015250 and water channel activity and molecular function this GO :0015288 and porin activity and molecular function this GO :0015670 and carbon dioxide transport and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0030104 and water homeostasis and biological process this GO :0030315 and T-tubule and cellular component this GO :0042383 and sarcolemma and cellular component this GO :0042538 and hyperosmotic salinity response and biological process this GO :0043234 and protein complex and cellular component this GO :0050891 and multicellular organismal water homeostasis and biological process this GO :0051260 and protein homooli this GO merization and biological process this GO :0051384 and response to glucocorticoid and biological process this GO :0055085 and transmembrane transport and biological process this GO :0070295 and renal water absorption and biological process this GO :0071346 and cellular response to interferon-gamma and biological process this GO :0071392 and cellular response to estradiol stimulus and biological process, this GO :0005215 : transporter activity, this GO :0005215 : transporter activity and also this GO :0005372 : water transmembrane transporter activity and also this GO :0015250 : water channel activity and also this GO :0015288 : porin activity, this GO :0005372 : water transmembrane transporter activity, this GO :0015250 : water channel activity, this GO :0015288 : porin activity, aquaporin 4 |
| Identity: |
637 |
| Gene: |
AQP4 |
More about : AQP4 |
| Long gene name: |
aquaporin 4 |
| Synonyms: |
MIWC |
| Locus: |
18q11, 2 |
| Discovery year: |
1994-07-25 |
| GenBank acession: |
U63622 |
| Entrez gene record: |
361 |
| Pubmed identfication: |
7528931 |
| RefSeq identity: |
NM_001650 NM_004028 |
| Classification: |
Aquaporins |
| Havana BLAST/BLAT: |
OTTHUMG00000131955 |