| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TACR1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the TACR1 antibody should be determined by the researcher |
| Intented use: |
This TACR1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P25103 |
| Purity: |
Antigen affinity |
| Description: |
Asp-Arg-Tyr, In fact, It is present in neurons, Lys/Arg-Lys/Arg-X-X-Lys/Arg, Other diseases in which the tachykinin receptor 1 system is involved include asthma, Tachykinin receptor 1, Tachykinin receptor 1 antagonists have also been studied in migraine, Tachykinin receptor 1 consists of 407 amino acid residues, The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, The endogenous ligand for this receptor is Substance P, The loops have functional sites, The protein is the product of the TACR1 gene, also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR), although it has some affinity for other tachykinins, an amino-terminus and a cytoplasmic carboxy-terminus, and it has a molecular weight of 58, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression, as well as the other tachykinin receptors, brainstem, emesis and psychiatric disorders, gastrointestinal tracts, genitourinary tract, including two cysteines amino acids for a disulfide bridge, is a G protein coupled receptor found in the central nervous system and peripheral nervous system, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, muscle, pulmonary tissue, rheumatoid arthritis and gastrointestinal disorders, the contraction of smooth muscles and inflammation, thyroid gland and different types of immune cells, vascular endothelial cells, which interacts with G-proteins, which is responsible for association with arrestin and, 000D, The tachykinin receptor 1 (TACR1), The tachykinin receptor 1 can be found in both the central and peripheral nervous system |
| Immunogen: |
Amino acids FHIFFLLPYINPDLYLKKFIQQVYLAIM of human TACR1 were used as the immunogen for the TACR1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TACR1 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TACR1 |
| Short name: |
TACR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
tachykinin receptor 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, Cell surfaces, GABAergic and biological process this GO :0032355 and response to estradiol and biological process this GO :0032570 and response to progesterone and biological process this GO :0035094 and response to nicotine and biological process this GO :0035106 and operant conditioning and biological process this GO :0035815 and positive regulation of renal sodium excretion and biological process this GO :0042713 and sperm ejaculation and biological process this GO :0042755 and eating behavior and biological process this GO :0043117 and positive regulation of vascular permeability and biological process this GO :0043278 and response to morphine and biological process this GO :0044297 and cell body and cellular component this GO :0045471 and response to ethanol and biological process this GO :0045760 and positive regulation of action potential and biological process this GO :0045777 and positive regulation of blood pressure and biological process this GO :0045778 and positive regulation of ossification and biological process this GO :0045907 and positive regulation of vasoconstriction and biological process this GO :0046878 and positive regulation of saliva secretion and biological process this GO :0046887 and positive regulation of hormone secretion and biological process this GO :0048265 and response to pain and biological process this GO :0048266 and behavioral response to pain and biological process this GO :0048660 and regulation of smooth muscle cell proliferation and biological process this GO :0050671 and positive regulation of lymphocyte proliferation and biological process this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0051496 and positive regulation of stress fiber assembly and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0060083 and smooth muscle contraction involved in micturition and biological process this GO :0070474 and positive regulation of uterine smooth muscle contraction and biological process this GO :0071944 and cell periphery and cellular component, NK1R and NKIR and SPR and TAC1R, TACR1 and IDBG-58132 and ENSG00000115353 and 6869, Tacr1 and IDBG-158953 and ENSMUSG00000030043 and 21336, cholinergic and biological process this GO :0032230 and positive regulation of synaptic transmission, substance P receptor activity, this GO :0002118 and aggressive behavior and biological process this GO :0002526 and acute inflammatory response and biological process this GO :0002687 and positive regulation of leukocyte migration and biological process this GO :0003051 and angiotensin-mediated drinking behavior and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004995 and tachykinin receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007200 and phospholipase C-activating G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007217 and tachykinin receptor signaling pathway and biological process this GO :0007611 and learning or memory and biological process this GO :0007616 and long-term memory and biological process this GO :0008217 and regulation of blood pressure and biological process this GO :0008306 and associative learning and biological process this GO :0009408 and response to heat and biological process this GO :0009582 and detection of abiotic stimulus and biological process this GO :0009725 and response to hormone and biological process this GO :0009986 and cell surface and cellular component this GO :0010193 and response to ozone and biological process this GO :0010634 and positive regulation of epithelial cell migration and biological process this GO :0010996 and response to auditory stimulus and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0014910 and regulation of smooth muscle cell migration and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016496 and substance P receptor activity and molecular function this GO :0030425 and dendrite and cellular component this GO :0032224 and positive regulation of synaptic transmission, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity and also this GO :0004995 : tachykinin receptor activity and also this GO :0005515 : protein binding and also this GO :0016496 : substance P receptor activity, this GO :0004995 : tachykinin receptor activity, this GO :0005515 : protein binding, this GO :0016496 : substance P receptor activity, 27987 and IDBG-631020 and ENSBTAG00000015575 and 407133, tachykinin receptor 1 |
| Identity: |
11526 |
| Gene: |
TACR1 |
More about : TACR1 |
| Long gene name: |
tachykinin receptor 1 |
| Synonyms gene: |
TAC1R |
| Synonyms: |
SPR NK1R NKIR |
| Locus: |
2p12 |
| Discovery year: |
1991-12-11 |
| GenBank acession: |
M76675 |
| Entrez gene record: |
6869 |
| Pubmed identfication: |
1657150 |
| RefSeq identity: |
NM_001058 |
| Classification: |
Tachykinin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000129973 |