| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
RALA |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the RALA antibody should be determined by the researcher |
| Intented use: |
This RALA antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P11233 |
| Purity: |
Antigen affinity |
| Description: |
Additionally, As a Ras GTPase, In particular, It can be activated by RalGEFs and, Moreover, Ral proteins have been associated with the progression of several cancers, RalA functions as a molecular switch that becomes active when bound to GTP and inactive when bound to GDP, RalA is more involved in anchorage-independent cell growth, RalA specifically interacts with Exo84 and Sec5 to regulate transport of membrane proteins in polarized epithelial cells and GLUT4 to the plasma membrane, This protein is one of two isoforms of the Ral protein, While the above functions appear to be shared between the two Ral isoforms, activate effectors in signal transduction pathways leading to biological outcomes, and cytoskeletal organization, and part of the Ras GTPase family, as well as mitochondrial fission for cell division, in turn, including bladder cancer and prostate cancer, the other being RalB, their differential subcellular localizations result in their differing involvement in certain biological processes, vesicle trafficking, Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7 |
| Immunogen: |
Amino acids DKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERC of human RALA were used as the immunogen for the RALA antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the RALA antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
RALA |
| Short name: |
RALA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
v-ral simian leukemia viral oncogene homolog A (ras related) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, Edg-2 lysophosphatidic acid receptor binding, RAL, RALA and IDBG-13210 and ENSG00000006451 and 5898, RALA and IDBG-634566 and ENSBTAG00000006661 and 538477, Rala and IDBG-132005 and ENSMUSG00000008859 and 56044, this GO :0000910 and cytokinesis and biological process this GO :0003924 and GTPase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005525 and GTP binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006184 and GTP catabolic process and biological process this GO :0006886 and intracellular protein transport and biological process this GO :0006887 and exocytosis and biological process this GO :0006913 and nucleocytoplasmic transport and biological process this GO :0006935 and chemotaxis and biological process this GO :0007165 and signal transduction and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0009986 and cell surface and cellular component this GO :0015031 and protein transport and biological process this GO :0016020 and membrane and cellular component this GO :0016032 and viral process and biological process this GO :0017157 and regulation of exocytosis and biological process this GO :0030139 and endocytic vesicle and cellular component this GO :0030496 and midbody and cellular component this GO :0030659 and cytoplasmic vesicle membrane and cellular component this GO :0031532 and actin cytoskeleton reorganization and biological process this GO :0031755 and Edg-2 lysophosphatidic acid receptor binding and molecular function this GO :0032154 and cleavage furrow and cellular component this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051491 and positive regulation of filopodium assembly and biological process this GO :0051665 and membrane raft localization and biological process this GO :0061024 and membrane organization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0003924 : GTPase activity, this GO :0003924 : GTPase activity and also this GO :0005515 : protein binding and also this GO :0005525 : GTP binding and also this GO :0031755 : Edg-2 lysophosphatidic acid receptor binding, this GO :0005515 : protein binding, this GO :0005525 : GTP binding, this GO :0031755 : Edg-2 lysophosphatidic acid receptor binding, v-ral simian leukemia viral oncogene homolog A (ras related) |
| Identity: |
9839 |
| Gene: |
RALA |
More about : RALA |
| Long gene name: |
RAS like proto-oncogene A |
| Synonyms gene: |
RAL |
| Synonyms gene name: |
v-ral simian leukemia viral oncogene homolog A (ras related) |
| Synonyms name: |
RAS-like protein A Ras-related protein Ral-A Ras family small GTP binding protein RALA ras related GTP binding protein A |
| Locus: |
7p14, 1 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
5898 |
| Pubmed identfication: |
3292391 |
| RefSeq identity: |
NM_005402 |
| Classification: |
RAS type GTPase family |
| Havana BLAST/BLAT: |
OTTHUMG00000128775 |