| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PRDX3 (Peroxiredoxin 3) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the PRDX3 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This PRDX3 antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
10935 |
| Purity: |
Antigen affinity |
| Description: |
Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1, Expression of Peroxiredoxin 3 is induced by MYC and is reduced in c-myc -/- cells, MER5, Results using mitochondria-specific fluorescent probes demonstrated that Peroxiredoxin 3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells, SP-22 or PRX3, The PRDX3 gene is mapped on 10q26, The deduced 256-amino acid human protein shares 86% amino acid sequence similarity with mouse, These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function, also known as AOP-1, and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23, is localized exclusively in mitochondria, 11, Peroxiredoxin 3 |
| Immunogen: |
Human partial recombinant protein (AA 110-256) was used as the immunogen for this PRDX3 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the PRDX3 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PRDX3 (Peroxiredoxin 3) |
| Short name: |
PRDX3 Antibody (Peroxiredoxin 3) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
peroxiredoxin 3 (Antibody to) (Peroxiredoxin 3) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AOP-1 and AOP1 and HBC189 and MER5 and PRO1748 and prx-III and SP-22, Cytoplasm, PRDX3 and IDBG-640354 and ENSBTAG00000008731 and 281998, PRDX3 and IDBG-91076 and ENSG00000165672 and 10935, Prdx3 and IDBG-181859 and ENSMUSG00000024997 and 11757, peroxiredoxin activity, this GO :0001893 and maternal placenta development and biological process this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0005769 and early endosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0006979 and response to oxidative stress and biological process this GO :0007005 and mitochondrion organization and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008379 and thioredoxin peroxidase activity and molecular function this GO :0008385 and IkappaB kinase complex and cellular component this GO :0008785 and alkyl hydroperoxide reductase activity and molecular function this GO :0016209 and antioxidant activity and molecular function this GO :0016491 and oxidoreductase activity and molecular function this GO :0018171 and peptidyl-cysteine oxidation and biological process this GO :0019900 and kinase binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030099 and myeloid cell differentiation and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0033673 and negative regulation of kinase activity and biological process this GO :0034599 and cellular response to oxidative stress and biological process this GO :0034614 and cellular response to reactive oxygen species and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042744 and hydrogen peroxide catabolic process and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043027 and cysteine-type endopeptidase inhibitor activity involved in apoptotic process and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043154 and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051881 and regulation of mitochondrial membrane potential and biological process this GO :0051920 and peroxiredoxin activity and molecular function this GO :0055114 and oxidation-reduction process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008022 : protein C-terminus binding and also this GO :0008379 : thioredoxin peroxidase activity and also this GO :0008785 : alkyl hydroperoxide reductase activity and also this GO :0016209 : antioxidant activity and also this GO :0016491 : oxidoreductase activity and also this GO :0019900 : kinase binding and also this GO :0019901 : protein kinase binding and also this GO :0042802 : identical protein binding and also this GO :0043027 : cysteine-type endopeptidase inhibitor activity involved in apoptotic process and also this GO :0051920 : peroxiredoxin activity, this GO :0008022 : protein C-terminus binding, this GO :0008379 : thioredoxin peroxidase activity, this GO :0008785 : alkyl hydroperoxide reductase activity, this GO :0016209 : antioxidant activity, this GO :0016491 : oxidoreductase activity, this GO :0019900 : kinase binding, this GO :0019901 : protein kinase binding, this GO :0042802 : identical protein binding, this GO :0043027 : cysteine-type endopeptidase inhibitor activity involved in apoptotic process, this GO :0051920 : peroxiredoxin activity, peroxiredoxin 3 |
| Identity: |
9354 |
| Gene: |
PRDX3 |
More about : PRDX3 |
| Long gene name: |
peroxiredoxin 3 |
| Synonyms gene: |
AOP1 |
| Synonyms gene name: |
antioxidant protein 1 |
| Synonyms: |
MER5 AOP-1 SP-22 |
| Locus: |
10q26, 11 |
| Discovery year: |
1999-08-12 |
| GenBank acession: |
D49396 |
| Entrez gene record: |
10935 |
| Pubmed identfication: |
7733872 9363753 |
| RefSeq identity: |
NM_006793 |
| Classification: |
Peroxiredoxins |
| Havana BLAST/BLAT: |
OTTHUMG00000019146 |