| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
MSH3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the MSH3 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This MSH3 antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
4437 |
| Purity: |
Antigen affinity |
| Description: |
Additionally, Both loss of expression and over expression of the protein can leader tocarcinogenic effects, It is mapped to 5q14, The most significant role of MSH3 in cancer is the suppression of tumors by repair of somatic mutations in DNA that occur as the result of base-base mispairs and insertion/deletion loops, The primary function of MSH3 is to maintain the stability of the genome and enact tumor suppression by forming the heterodimer MutS<, also known as MRP1 or DUP, is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system, it has been shown that inactivation of the gene may be involved in the development of hematologic malignancies, to correct long insertion/deletion loops and base-base mispairs, /font>, 1, MutS homolog 3 (MSH3), b<, font face=symbol> |
| Immunogen: |
Human partial recombinant protein (AA 434-739) was used as the immunogen for this MSH3 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the MSH3 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
MSH3 |
| Short name: |
MSH3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
coli) (Antibody to), mutS homolog 3 (E |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DUP and MRP1, MSH3 and IDBG-31502 and ENSG00000113318 and 4437, MSH3 and IDBG-646483 and ENSBTAG00000007684 and 616744, Msh3 and IDBG-171801 and ENSMUSG00000014850 and 17686, coli), nuclei, oxidized purine DNA binding, this GO :0000228 and nuclear chromosome and cellular component this GO :0000403 and Y-form DNA binding and molecular function this GO :0000404 and heteroduplex DNA loop binding and molecular function this GO :0000406 and double-strand/single-strand DNA junction binding and molecular function this GO :0000710 and meiotic mismatch repair and biological process this GO :0003677 and DNA binding and molecular function this GO :0003684 and damaged DNA binding and molecular function this GO :0003697 and single-stranded DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006281 and DNA repair and biological process this GO :0006298 and mismatch repair and biological process this GO :0007131 and reciprocal meiotic recombination and biological process this GO :0008094 and DNA-dependent ATPase activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016447 and somatic recombination of immunoglobulin gene segments and biological process this GO :0019237 and centromeric DNA binding and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0030983 and mismatched DNA binding and molecular function this GO :0032139 and dinucleotide insertion or deletion binding and molecular function this GO :0032142 and single guanine insertion binding and molecular function this GO :0032181 and dinucleotide repeat insertion binding and molecular function this GO :0032302 and MutSbeta complex and cellular component this GO :0032357 and oxidized purine DNA binding and molecular function this GO :0043570 and maintenance of DNA repeat elements and biological process this GO :0045910 and negative regulation of DNA recombination and biological process this GO :0051096 and positive regulation of helicase activity and biological process, this GO :0000403 : Y-form DNA binding, this GO :0000403 : Y-form DNA binding and also this GO :0000404 : heteroduplex DNA loop binding and also this GO :0000406 : double-strand/single-strand DNA junction binding and also this GO :0003677 : DNA binding and also this GO :0003684 : damaged DNA binding and also this GO :0003697 : single-stranded DNA binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008094 : DNA-dependent ATPase activity and also this GO :0019237 : centromeric DNA binding and also this GO :0019899 : enzyme binding and also this GO :0030983 : mismatched DNA binding and also this GO :0032139 : dinucleotide insertion or deletion binding and also this GO :0032142 : single guanine insertion binding and also this GO :0032181 : dinucleotide repeat insertion binding and also this GO :0032357 : oxidized purine DNA binding, this GO :0000404 : heteroduplex DNA loop binding, this GO :0000406 : double-strand/single-strand DNA junction binding, this GO :0003677 : DNA binding, this GO :0003684 : damaged DNA binding, this GO :0003697 : single-stranded DNA binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008094 : DNA-dependent ATPase activity, this GO :0019237 : centromeric DNA binding, this GO :0019899 : enzyme binding, this GO :0030983 : mismatched DNA binding, this GO :0032139 : dinucleotide insertion or deletion binding, this GO :0032142 : single guanine insertion binding, this GO :0032181 : dinucleotide repeat insertion binding, this GO :0032357 : oxidized purine DNA binding, mutS homolog 3 (E |
| Identity: |
7326 |
| Gene: |
MSH3 |
More about : MSH3 |
| Long gene name: |
mutS homolog 3 |
| Synonyms gene name: |
coli) , coli) homolog 3 mutS homolog 3 (E, mutS (E |
| Synonyms: |
DUP MRP1 |
| Synonyms name: |
Divergent upstream protein Mismatch repair protein 1 |
| Locus: |
5q14, 1 |
| Discovery year: |
1995-09-28 |
| GenBank acession: |
U61981 |
| Entrez gene record: |
4437 |
| RefSeq identity: |
NM_002439 |
| Classification: |
MutS homologs |
| Havana BLAST/BLAT: |
OTTHUMG00000162540 |