| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HNF4A |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the HNF4A antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This HNF4A antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P41235 |
| Purity: |
Antigen affinity |
| Description: |
HNF4A controls the expression of several genes, HNF4A is required for the PXR and CAR-mediated transcriptional activation of<, It is a nuclear transcription factor that binds DNA as a homodimer, This gene also plays a pivotal role in the expression and synthesis of SHBG, This gene plays a role in development of the liver, a transcription factor which regulates the expression of several hepatic genes, also known as NR2A1, an important glycoprotein made primarily in the liver, and intestines, including<, is a nuclear receptor that in humans is encoded by the HNF4A gene, kidney, which in addition to lowering insulin-resistance also serves in reducing levels of free Oestrogen as-well as prolonging the half-life of Testosterone, /a>, /a>, /search_result, /search_result, CYP3A4<, HNF1A<, Hepatocyte nuclear factor 4 alpha, a href=, a href=, php?search_txt=cyp3a4>, php?search_txt=hnf1a> |
| Immunogen: |
Human partial recombinant protein (AA 164-474) was used as the immunogen for this HNF4A antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the HNF4A antibody can be stored for up to one month at 4oC, After reconstitution |
| Localization: |
Intracellular |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HNF4A |
| Short name: |
HNF4A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HNF4A (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5024 |
| Gene: |
HNF4A |
More about : HNF4A |
| Long gene name: |
hepatocyte nuclear factor 4 alpha |
| Synonyms gene: |
TCF14 MODY MODY1 |
| Synonyms: |
NR2A1 HNF4 |
| Locus: |
20q13, 12 |
| Discovery year: |
1998-04-20 |
| GenBank acession: |
X76930 |
| Entrez gene record: |
3172 |
| Pubmed identfication: |
7926813 9048927 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000032531 |
| Locus Specific Databases: |
Monogenic Diabetes LRG_483 |