| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
NALP3 (NLRP3) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the NALP3 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This NALP3 antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
114548 |
| Purity: |
Antigen affinity |
| Description: |
Activation of the NLRP3 inflammasome in response to virus or to RNA was dependent upon lysosomal maturation and reactive oxygen species production in human cells, CRYOPYRIN, Consistent with an essential role for NALP3 inflammasomes in antifungal immunity, It is mapped to 1q44, NALP3 or PYPAF1, Pyrin domain containing 3, The encoded protein may play a role in the regulation of inflammation and apoptosis, The inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance, albicans infection, also known as CIAS1, is a protein that in humans is encoded by the NLRP3 gene, it has been showed that deficient mice are hypersusceptible to C, NLR Family |
| Immunogen: |
Human partial recombinant protein (21-194) was used as the immunogen for this NLRP3 / NALP3 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the NALP3 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
NALP3 (NLRP3) |
| Short name: |
NALP3 Antibody (NLRP3) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
pyrin domain containing 3), NALP3 (Antibody to) (NLR family |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cytoplasm, NLRP3 and IDBG-107914 and ENSG00000162711 and 114548, NLRP3 and IDBG-645402 and ENSBTAG00000001273 and 538639, Nlrp3 and IDBG-178924 and ENSMUSG00000032691 and 216799, leucine rich repeat containing receptor signaling pathway and biological process this GO :0042347 and negative regulation of NF-kappaB import into nucleus and biological process this GO :0042834 and peptidoglycan binding and molecular function this GO :0043280 and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0044546 and NLRP3 inflammasome complex assembly and biological process this GO :0045087 and innate immune response and biological process this GO :0050701 and interleukin-1 secretion and biological process this GO :0050713 and negative regulation of interleukin-1 beta secretion and biological process this GO :0050718 and positive regulation of interleukin-1 beta secretion and biological process this GO :0050727 and regulation of inflammatory response and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051259 and protein oli this GO merization and biological process this GO :0051607 and defense response to virus and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0072559 and NLRP3 inflammasome complex and cellular component, peptidoglycan binding, pyrin domain containing 3, this GO :0002674 and negative regulation of acute inflammatory response and biological process this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006952 and defense response and biological process this GO :0006954 and inflammatory response and biological process this GO :0007165 and signal transduction and biological process this GO :0009595 and detection of biotic stimulus and biological process this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0032611 and interleukin-1 beta production and biological process this GO :0032621 and interleukin-18 production and biological process this GO :0035872 and nucleotide-binding domain, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0042834 : peptidoglycan binding, this GO :0005524 : ATP binding, this GO :0042834 : peptidoglycan binding, NLR family |
| Identity: |
16400 |
| Gene: |
NLRP3 |
More about : NLRP3 |
| Long gene name: |
NLR family pyrin domain containing 3 |
| Synonyms gene: |
C1orf7 CIAS1 |
| Synonyms gene name: |
cold autoinflammatory syndrome 1 |
| Synonyms: |
AGTAVPRL AII AVP FCAS FCU NALP3 PYPAF1 MWS CLR1, 1 |
| Synonyms name: |
Cryopyrin nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 |
| Locus: |
1q44 |
| Discovery year: |
2001-08-28 |
| GenBank acession: |
AF054176 |
| Entrez gene record: |
114548 |
| Pubmed identfication: |
10741953 |
| RefSeq identity: |
NM_004895 |
| Classification: |
NLR family Pyrin domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000040647 |
| Locus Specific Databases: |
INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations LRG_197 |