| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
NCOA3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the NCOA3 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This NCOA3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9Y6Q9 |
| Purity: |
Antigen affinity |
| Description: |
In addition, In this way, It is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity, NCOA3, This gene was amplified and overexpressed in breast and ovarian cancer cell lines, acylates histones, and altered NCOA3 expression may contribute to development of steroid-dependent cancers, as well as in breast cancer biopsies, in turn, it assists nuclear receptors in the upregulation of gene expression, this gene is recruited to DNA promotion sites by ligand-activated nuclear receptors, which makes downsteam DNA more accessible to transcription, The Nuclear receptor coactivator 3 is encoded by the NCOA3 gene |
| Immunogen: |
An amino acid sequence from the C-terminus of human Nuclear receptor coactivator 3 (NLEGQSDERALLDQLHTLL) was used as the immunogen for this NCOA3 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the NCOA3 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
NCOA3 |
| Short name: |
NCOA3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NCOA3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7670 |
| Gene: |
NCOA3 |
More about : NCOA3 |
| Long gene name: |
nuclear receptor coactivator 3 |
| Synonyms: |
RAC3 AIB1 ACTR p/CIP TRAM-1 CAGH16 TNRC16 KAT13B bHLHe42 SRC-3 SRC3 |
| Synonyms name: |
receptor-associated coactivator 3 thyroid hormone receptor activator molecule 1 |
| Locus: |
20q13, 12 |
| Discovery year: |
1999-12-17 |
| GenBank acession: |
AF012108 |
| Entrez gene record: |
8202 |
| Pubmed identfication: |
9252329 9346901 |
| RefSeq identity: |
NM_006534 |
| Classification: |
Basic helix-loop-helix proteins Lysine acetyltransferases Trinucleotide repeat containing |
| Havana BLAST/BLAT: |
OTTHUMG00000033061 |