| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CFTR |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the CFTR antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CFTR antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P13569 |
| Purity: |
Antigen affinity |
| Description: |
ABC genes are divided into seven distinct subfamilies (ABC1, ABC proteins transport various molecules across extra- and intra-cellular membranes, ALD, GCN20, MDR/TAP, MRP, Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens, OABP, The encoded protein functions as a chloride channel and controls the regulation of other transport pathways, This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily, This gene is mapped to 7q31, This protein is a member of the MRP subfamily that is involved in multi-drug resistance, White), also called ABC35 or ABCC7, is a protein that in humans is encoded by the CFTR gene, 2, Cystic fibrosis transmembrane conductance regulator |
| Immunogen: |
An amino acid sequence from the C-terminus of human CFTR (QIAALKEETEEEVQDTRL) was used as the immunogen for this CFTR antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CFTR antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CFTR |
| Short name: |
CFTR Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
member 7) (Antibody to), cystic fibrosis transmembrane conductance regulator (adenosine triphosphate-binding cassette sub-family C |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ABC35 and ABCC7 and CF and CFTR/MRP and dJ760C5, ATPase activity, CFTR and IDBG-37713 and ENSG00000001626 and 1080, CFTR and IDBG-632747 and ENSBTAG00000006589 and 281067, Cell surfaces, Cftr and IDBG-129229 and ENSMUSG00000041301 and 12638, coupled to transmembrane movement of substances, coupled to transmembrane movement of substances, coupled to transmembrane movement of substances and molecular function this GO :0043234 and protein complex and cellular component this GO :0043434 and response to peptide hormone and biological process this GO :0043627 and response to estrogen and biological process this GO :0045087 and innate immune response and biological process this GO :0045909 and positive regulation of vasodilation and biological process this GO :0048240 and sperm capacitation and biological process this GO :0051454 and intracellular pH elevation and biological process this GO :0055085 and transmembrane transport and biological process this GO :0060081 and membrane hyperpolarization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071320 and cellular response to cAMP and biological process this GO :1902476 and chloride transmembrane transport and biological process this GO :1902943 and positive regulation of voltage-gated chloride channel activity and biological process, member 7), this GO :0005224 and ATP-binding and phosphorylation-dependent chloride channel activity and molecular function this GO :0005254 and chloride channel activity and molecular function this GO :0005260 and channel-conductance-controlling ATPase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005769 and early endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005902 and microvillus and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006695 and cholesterol biosynthetic process and biological process this GO :0006810 and transport and biological process this GO :0006811 and ion transport and biological process this GO :0006821 and chloride transport and biological process this GO :0006833 and water transport and biological process this GO :0007585 and respiratory gaseous exchange and biological process this GO :0009986 and cell surface and cellular component this GO :0015106 and bicarbonate transmembrane transporter activity and molecular function this GO :0015108 and chloride transmembrane transporter activity and molecular function this GO :0015701 and bicarbonate transport and biological process this GO :0015705 and iodide transport and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0016887 and ATPase activity and molecular function this GO :0019869 and chloride channel inhibitor activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0030165 and PDZ domain binding and molecular function this GO :0030301 and cholesterol transport and biological process this GO :0030321 and transepithelial chloride transport and biological process this GO :0030324 and lung development and biological process this GO :0030659 and cytoplasmic vesicle membrane and cellular component this GO :0031205 and endoplasmic reticulum Sec complex and cellular component this GO :0031901 and early endosome membrane and cellular component this GO :0032870 and cellular response to hormone stimulus and biological process this GO :0034097 and response to cytokine and biological process this GO :0034707 and chloride channel complex and cellular component this GO :0042311 and vasodilation and biological process this GO :0042493 and response to drug and biological process this GO :0042626 and ATPase activity, this GO :0005224 : ATP-binding and phosphorylation-dependent chloride channel activity, this GO :0005224 : ATP-binding and phosphorylation-dependent chloride channel activity and also this GO :0005254 : chloride channel activity and also this GO :0005260 : channel-conductance-controlling ATPase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0015106 : bicarbonate transmembrane transporter activity and also this GO :0015108 : chloride transmembrane transporter activity and also this GO :0016887 : ATPase activity and also this GO :0019869 : chloride channel inhibitor activity and also this GO :0019899 : enzyme binding and also this GO :0030165 : PDZ domain binding and also this GO :0042626 : ATPase activity, this GO :0005254 : chloride channel activity, this GO :0005260 : channel-conductance-controlling ATPase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0015106 : bicarbonate transmembrane transporter activity, this GO :0015108 : chloride transmembrane transporter activity, this GO :0016887 : ATPase activity, this GO :0019869 : chloride channel inhibitor activity, this GO :0019899 : enzyme binding, this GO :0030165 : PDZ domain binding, this GO :0042626 : ATPase activity, 1 and MRP7 and TNR-CFTR, cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C |
| Identity: |
1884 |
| Gene: |
CFTR |
More about : CFTR |
| Long gene name: |
cystic fibrosis transmembrane conductance regulator |
| Synonyms gene: |
CF ABCC7 |
| Synonyms gene name: |
ATP-binding cassette (sub-family C, cystic fibrosis transmembrane conductance regulator, member 7) |
| Synonyms: |
MRP7 ABC35 TNR-CFTR dJ760C5, 1 CFTR/MRP |
| Synonyms name: |
ATP-binding cassette sub-family C, member 7 |
| Locus: |
7q31, 2 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M28668 |
| Entrez gene record: |
1080 |
| Pubmed identfication: |
2772657 |
| RefSeq identity: |
NM_000492 |
| Classification: |
ATP-gated CFTR ATP binding cassette subfamily C , Chloride channels |
| Havana BLAST/BLAT: |
OTTHUMG00000023076 |
| Locus Specific Databases: |
Cystic Fibrosis LRG_663 |