| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
LAMA2 Laminin 2 alpha |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the LAMA2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting points |
| Intented use: |
This LAMA2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P24043 |
| Purity: |
Antigen affinity |
| Description: |
It is composed of three subunits, It is though to mediate the attachment, Laminin, Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy, This gene encodes the alpha 2 chain, This gene is mapped to 6q22, Two transcript variants encoding different proteins have been found for this gene, alpha, an extracellular protein, and gamma, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components, beta, is a major component of the basement membrane, migration, which are bound to each other by disulfide bonds into a cross-shaped molecule, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin), 33, Laminin 2 alpha is a protein that in humans is encoded by the LAMA2 gene |
| Immunogen: |
Amino acids 152-170 (WILERSLDDVEYKPWQYHA-human) were used as the immunogen for this LAMA2 antibody (100% mouse homology) |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the LAMA2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
LAMA2 Laminin 2 alpha |
| Short name: |
LAMA2 Antibody Laminin 2 alpha |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
alpha 2 (Antibody to) Laminin 2 a, laminin |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, LAMA2 and IDBG-632972 and ENSBTAG00000010229 and 100138434, LAMA2 and IDBG-96327 and ENSG00000196569 and 3908, LAMM, Lama2 and IDBG-140720 and ENSMUSG00000019899 and 16773, alpha 2, cholinergic and biological process this GO :0042383 and sarcolemma and cellular component this GO :0043197 and dendritic spine and cellular component this GO :0045995 and regulation of embryonic development and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, protein binding, this GO :0005102 and receptor binding and molecular function this GO :0005198 and structural molecule activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005604 and basement membrane and cellular component this GO :0005605 and basal lamina and cellular component this GO :0005606 and laminin-1 complex and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007411 and axon guidance and biological process this GO :0007517 and muscle organ development and biological process this GO :0016020 and membrane and cellular component this GO :0016192 and vesicle-mediated transport and biological process this GO :0022011 and myelination in peripheral nervous system and biological process this GO :0030155 and regulation of cell adhesion and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030334 and regulation of cell migration and biological process this GO :0031012 and extracellular matrix and cellular component this GO :0032224 and positive regulation of synaptic transmission, this GO :0005102 : receptor binding, this GO :0005102 : receptor binding and also this GO :0005198 : structural molecule activity and also this GO :0005515 : protein binding, this GO :0005198 : structural molecule activity, this GO :0005515 : protein binding, 100848461, 101904210, 101910012, laminin |
| Identity: |
6482 |
| Gene: |
LAMA2 |
More about : LAMA2 |
| Long gene name: |
laminin subunit alpha 2 |
| Synonyms gene: |
LAMM |
| Synonyms gene name: |
alpha 2 , laminin |
| Synonyms name: |
merosin congenital muscular dystrophy |
| Locus: |
6q22, 33 |
| Discovery year: |
1992-05-06 |
| GenBank acession: |
Z26653 |
| Entrez gene record: |
3908 |
| Pubmed identfication: |
2185464 8294519 |
| Classification: |
Laminin subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000015545 |
| Locus Specific Databases: |
Leiden Muscular Dystrophy Pages Leiden Muscular Dystrophy pages LRG_409 |