| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
OPG Osteoprotegerin |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the OPG antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This OPG antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O00300 |
| Purity: |
Antigen affinity |
| Description: |
By analysis of radiation hybrids, By binding RANKL, OPG inhibits nuclear kappa B (NF-kappa B) which is a central and rapid acting transcription factor for immune-related genes, OPG is a cytokine receptor, Osteoprotegerin binding to RANKL on osteoblast/stromal cells, TNFRSF11B gene was mapped to chromosome 8q24, The protein is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL), also known as Osteoprotegerin and OPG, and a key regulator of inflammation, and a member of the tumor necrosis factor (TNF) receptor superfamily, and cell survival and differentiation, blocks the RANK-RANK ligand interaction between osteoblast/stromal cells and ostepclast precursors, innate immunity, is a protein that in humans is encoded by the TNFRSF11B gene, Tumor necrosis factor receptor superfamily member 11B |
| Immunogen: |
An amino acid sequence from the C-terminus of human Osteoprotegerin (IRFLHSFTMYKLYQKLFLEMI) was used as the immunogen for this OPG antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the OPG antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
OPG Osteoprotegerin |
| Short name: |
OPG Antibody Osteoprotegerin |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
OPG (Antibody to) Osteoprotegerin |
| Alternative technique: |
antibodies |
| Identity: |
11909 |
| Gene: |
TNFRSF11B |
More about : TNFRSF11B |
| Long gene name: |
TNF receptor superfamily member 11b |
| Synonyms gene: |
OPG |
| Synonyms gene name: |
member 11b , osteoprotegerin tumor necrosis factor receptor superfamily |
| Synonyms: |
OCIF TR1 |
| Locus: |
8q24, 12 |
| Discovery year: |
1997-09-05 |
| GenBank acession: |
U94332 |
| Entrez gene record: |
4982 |
| Pubmed identfication: |
9108485 |
| Classification: |
Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000164969 |