| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
BAG3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the BAG3 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This BAG3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O95817 |
| Purity: |
Antigen affinity |
| Description: |
BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes, BAG3 mutations are responsible for familial dilated cardiomyopathy, In muscle cells, Polymorphisms are also associated with sporadic forms of the disease together with HSPB7 locus, This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity in flies, mice and men, BAG family molecular chaperone regulator 3 is a member of a conserved family of cyto-protective proteins that bind to and regulate Hsp70 family molecular chaperones |
| Immunogen: |
mouse and rat), An amino acid sequence from the C-terminus of human BAG family molecular chaperone regulator 3 (LEKLEQKAIDVPGQVQ) was used as the immunogen for this Bag3 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the BAG3 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
BAG3 |
| Short name: |
BAG3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
B-cell CLL/lymphoma 2-associated athanogene 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BAG-3 and BIS and CAIR-1 and MFM6, BAG3 and IDBG-91218 and ENSG00000151929 and 9531, BT, Bag3 and IDBG-210660 and ENSMUSG00000030847 and 29810, Plasma membranes, chaperone binding, this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006457 and protein folding and biological process this GO :0007420 and brain development and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0010664 and negative regulation of striated muscle cell apoptotic process and biological process this GO :0021510 and spinal cord development and biological process this GO :0030018 and Z disc and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0050821 and protein stabilization and biological process this GO :0051087 and chaperone binding and molecular function this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0032403 : protein complex binding and also this GO :0051087 : chaperone binding, this GO :0032403 : protein complex binding, this GO :0051087 : chaperone binding, 65578 and IDBG-640385 and ENSBTAG00000013641 and 782633, BCL2-associated athanogene 3 |
| Identity: |
939 |
| Gene: |
BAG3 |
More about : BAG3 |
| Long gene name: |
BCL2 associated athanogene 3 |
| Locus: |
10q26, 11 |
| Discovery year: |
1999-04-23 |
| GenBank acession: |
AF095193 |
| Entrez gene record: |
9531 |
| Pubmed identfication: |
9873016 18094623 |
| RefSeq identity: |
NM_004281 |
| Classification: |
BCL2 associated athanogene family |
| Havana BLAST/BLAT: |
OTTHUMG00000019155 |
| Locus Specific Databases: |
LRG_742 |