| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
MALT1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the MALT1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This MALT1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9UDY8 |
| Purity: |
Antigen affinity |
| Description: |
Dierlamm et al, MALT1 operates downstream of BCL10, Ruland et al, This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3(also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas, Using mouse models, also called MLT or Paracaspase, and IL2 production in response to T-cell receptor ligation and strictly required for signal-specific NF-kappa-B(NFKB) activation induced by the T-cell receptor but not TNF-alpha or IL1 signaling, and regulates the signaling of JNK and p38 MAP kinases, controls the catalytic activity of the canonical I-kappa-B kinase complex, is a protein that in humans is encoded by the MALT1 gene, proliferation, (1999) and Akagi et al, (1999) mapped the gene to chromosome 18q21, (2003) demonstrated that MALT1 is essential for T-cell activation, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
| Immunogen: |
An amino acid sequence from the C-terminus of human MALT1 (DEIPFSFSDRLRISEK) was used as the immunogen for this MALT1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the MALT1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
MALT1 |
| Short name: |
MALT1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
mucosa associated lymphoid tissue lymphoma translocation gene 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
IMD12 and MLT and MLT1, MALT1 and IDBG-3930 and ENSG00000172175 and 10892, MALT1 and IDBG-644866 and ENSBTAG00000027916 and 504994, Malt1 and IDBG-154592 and ENSMUSG00000032688 and 240354, nuclei, protein self-association, this GO :0001923 and B-1 B cell differentiation and biological process this GO :0002020 and protease binding and molecular function this GO :0002237 and response to molecule of bacterial origin and biological process this GO :0002726 and positive regulation of T cell cytokine production and biological process this GO :0004197 and cysteine-type endopeptidase activity and molecular function this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006508 and proteolysis and biological process this GO :0006952 and defense response and biological process this GO :0007250 and activation of NF-kappaB-inducing kinase activity and biological process this GO :0008233 and peptidase activity and molecular function this GO :0009620 and response to fungus and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0019209 and kinase activator activity and molecular function this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0032449 and CBM complex and cellular component this GO :0032743 and positive regulation of interleukin-2 production and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042098 and T cell proliferation and biological process this GO :0042113 and B cell activation and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0043621 and protein self-association and molecular function this GO :0045087 and innate immune response and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050856 and regulation of T cell receptor signaling pathway and biological process this GO :0050870 and positive regulation of T cell activation and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051168 and nuclear export and biological process this GO :0051259 and protein oli this GO merization and biological process, this GO :0002020 : protease binding, this GO :0002020 : protease binding and also this GO :0004197 : cysteine-type endopeptidase activity and also this GO :0004842 : ubiquitin-protein transferase activity and also this GO :0004871 : signal transducer activity and also this GO :0005515 : protein binding and also this GO :0008233 : peptidase activity and also this GO :0019209 : kinase activator activity and also this GO :0043621 : protein self-association, this GO :0004197 : cysteine-type endopeptidase activity, this GO :0004842 : ubiquitin-protein transferase activity, this GO :0004871 : signal transducer activity, this GO :0005515 : protein binding, this GO :0008233 : peptidase activity, this GO :0019209 : kinase activator activity, this GO :0043621 : protein self-association, mucosa associated lymphoid tissue lymphoma translocation gene 1 |
| Identity: |
6819 |
| Gene: |
MALT1 |
More about : MALT1 |
| Long gene name: |
MALT1 paracaspase |
| Synonyms gene: |
MLT |
| Synonyms gene name: |
mucosa associated lymphoid tissue lymphoma translocation gene 1 |
| Synonyms: |
PCASP1 |
| Synonyms name: |
MALT1 protease paracaspase 1 |
| Locus: |
18q21, 32 |
| Discovery year: |
1999-08-02 |
| Entrez gene record: |
10892 |
| Pubmed identfication: |
10339464 10406266 10523859 11090634 26377317 |
| RefSeq identity: |
NM_006785 |
| Classification: |
Immunoglobulin like domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000132761 |