| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
FSTL3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the FSTL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This FSTL3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O95633 |
| Purity: |
Antigen affinity |
| Description: |
By Southern blot analysis of somatic cell hybrids and FISH, Hayette et al, Hayette et al, In addition to the translocation in a case of B-cell chronic lymphocytic leukemia from which FSTL3 was isolated, Overexpression of the protein inhibited BMP2-induced cell signaling in a reporter assay, The FSTL3 gene extends over 7 kbp and contains 5 exons, Tsuchida et al, Using recombinant mouse protein, also known as FLRG, is a member of the follistatin-module protein family, suggesting that FSTL3 may be involved in the leukemogenesis process, which is composed of extracellular matrix-associated glycoproteins thought to act in a paracrine manner to bind morphogens or growth/differentiation factors and regulate their activity during development, (1998) also observed rearrangement of the gene in a case of B-cell non-Hodgkin lymphoma and in a case of B-cell mantle zone lymphoma, (1998) localized the gene to chromosome 19p13, (2000) found that FSTL3 bound both activin and BMP2 and had a higher affinity for activin, Follistatin-Like 3 |
| Immunogen: |
Amino acids 145-159 (ECELRAARCRGHPDL-human) were used as the immunogen for this FSTL3 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the FSTL3 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
FSTL3 |
| Short name: |
FSTL3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
follistatin-like 3 (secreted glycoprotein) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0007283 and spermatogenesis and biological process this GO :0008584 and male this GO nad development and biological process this GO :0022409 and positive regulation of cell-cell adhesion and biological process this GO :0030141 and secretory granule and cellular component this GO :0030324 and lung development and biological process this GO :0030325 and adrenal gland development and biological process this GO :0030514 and negative regulation of BMP signaling pathway and biological process this GO :0032926 and negative regulation of activin receptor signaling pathway and biological process this GO :0044306 and neuron projection terminus and cellular component this GO :0045671 and negative regulation of osteoclast differentiation and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048185 and activin binding and molecular function this GO :0071248 and cellular response to metal ion and biological process this GO :0090101 and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway and biological process, FLRG and FSRP, FSTL3 and IDBG-12738 and ENSG00000070404 and 10272, FSTL3 and IDBG-645504 and ENSBTAG00000003018 and 515367, Fstl3 and IDBG-170833 and ENSMUSG00000020325 and 83554, activin binding, nuclei, this GO :0001503 and ossification and biological process this GO :0001822 and kidney development and biological process this GO :0001968 and fibronectin binding and molecular function this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0006351 and transcription, this GO :0001968 : fibronectin binding, this GO :0001968 : fibronectin binding and also this GO :0005515 : protein binding and also this GO :0048185 : activin binding, this GO :0005515 : protein binding, this GO :0048185 : activin binding, follistatin-like 3 (secreted glycoprotein) |
| Identity: |
3973 |
| Gene: |
FSTL3 |
More about : FSTL3 |
| Long gene name: |
follistatin like 3 |
| Synonyms gene name: |
follistatin-like 3 (secreted glycoprotein) |
| Synonyms: |
FLRG FSRP |
| Synonyms name: |
follistatin-related protein |
| Locus: |
19p13, 3 |
| Discovery year: |
1999-09-07 |
| GenBank acession: |
U76702 |
| Entrez gene record: |
10272 |
| Pubmed identfication: |
9671416 15527507 |
| RefSeq identity: |
NM_005860 |
| Havana BLAST/BLAT: |
OTTHUMG00000180593 |