| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
BOC |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the BOC antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This BOC antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q6AZB0 |
| Purity: |
Antigen affinity |
| Description: |
BOC is dependent on CDON for activity and that CDON/BOC complexes function to regulate myogenic differentiation, CDON and BOC are coexpressed during development, In contrast with CDON, The International Radiation Hybrid Mapping Consortium mapped the gene to chromosome 3, The domain structure of BOC is similar to that of CDON, The protein is expressed by commissural neurons, Wegorzewska et al, also known as 'Brother of CDON' and BOC are cell surface receptors of the immunoglobulin(Ig)/fibronectin type III repeat family involved in myogenic differentiation, and are related to each other in their ectodomains, and targeted disruption of it in mouse resulted in the misguidance of commissural axons toward the floor plate, and the proteins share 38 to 80% amino acid identity in the individual extracellular domains, but each has a unique long cytoplasmic tail, form complexes with each other in a cis fashion, the intracellular region of BOC was not essential for its ability to positively regulate differentiation, (2003) proposed that CDO and BOC play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage, Brother Of CDO |
| Immunogen: |
Amino acids 1002-1020 (DDSTHQLLQPQDCCHLQKQ-mouse) were used as the immunogen for this BOC antibody (100% rat homology) |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the BOC antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
BOC |
| Short name: |
BOC Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Boc homolog (mouse) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BOC and IDBG-50192 and ENSG00000144857 and 91653, BOC and IDBG-632359 and ENSBTAG00000013909 and 512018, Boc and IDBG-162156 and ENSMUSG00000022687 and 117606, Plasma membranes, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007224 and smoothened signaling pathway and biological process this GO :0007411 and axon guidance and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0030030 and cell projection organization and biological process this GO :0030424 and axon and cellular component this GO :0030426 and growth cone and cellular component this GO :0042692 and muscle cell differentiation and biological process this GO :0043025 and neuronal cell body and cellular component this GO :0044295 and axonal growth cone and cellular component this GO :0045663 and positive regulation of myoblast differentiation and biological process this GO :0051149 and positive regulation of muscle cell differentiation and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, Boc homolog (mouse) |
| Identity: |
17173 |
| Gene: |
BOC |
More about : BOC |
| Long gene name: |
BOC cell adhesion associated, oncogene regulated |
| Synonyms gene name: |
Boc homolog (mouse) |
| Synonyms: |
CDON2 |
| Synonyms name: |
brother of CDO brother of CDON cell adhesion associated, oncogene regulated 2 |
| Locus: |
3q13, 2 |
| Discovery year: |
2006-02-02 |
| GenBank acession: |
AY027658 |
| Entrez gene record: |
91653 |
| Pubmed identfication: |
11782431 |
| RefSeq identity: |
NM_033254 |
| Classification: |
I-set domain containing Immunoglobulin like domain containing Fibronectin type III domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000159305 |