| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TRAIL R2 (DR5) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the TRAIL R2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting points |
| Intented use: |
This TRAIL R2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O14763 |
| Purity: |
Antigen affinity |
| Description: |
By analysis of radiation hybrid panels, CD262, KILLER, KILLER/DR5, Mice have a homologous gene, Northern blot analysis indicated that TRAIL R2 was expressed as a 4, Studies with FADD-deficient mice suggested that FADD, TRAIL R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, The protein encoded by this gene is a member of the TNF-receptor superfamily, This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), Walczak et al, ZTNFR9, a death domain containing adaptor protein, and contains an intracellular death domain, and ovary, and transduces apoptosis signal, including DR5, is required for the apoptosis mediated by this protein, member 10b) has many names, spleen, that has been essential in the elucidation of the function of this gene in humans, tnfrsf10b, with the highest levels of expression in peripheral blood lymphocytes, (1997) mapped the gene to chromosome 8p22-p21, 4-kb mRNA in all tissues tested, TNFRSF10B (Tumor necrosis factor receptor superfamily |
| Immunogen: |
An amino acid sequence from the C-terminus of human DR5/TRAIL R2 (DPTETLRQCFDDFADL) was used as the immunogen for this TRAIL R2 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TRAIL R2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TRAIL R2 (DR5) |
| Short name: |
TRAIL R2 Antibody (DR5) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TRAIL R2 (Antibody to) (DR5) |
| Alternative technique: |
antibodies |
| Identity: |
11925 |
| Gene: |
TNFSF10 |
More about : TNFSF10 |
| Long gene name: |
tumor necrosis factor superfamily member 10 |
| Synonyms gene name: |
member 10 , tumor necrosis factor (ligand) superfamily |
| Synonyms: |
TRAIL Apo-2L TL2 CD253 |
| Locus: |
3q26 |
| Discovery year: |
1998-12-04 |
| GenBank acession: |
U37518 |
| Pubmed identfication: |
8777713 8663110 |
| Classification: |
Tumor necrosis factor superfamily CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000156917 |