| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TRPC6 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the TRPC6 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This TRPC6 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9Y210 |
| Purity: |
Antigen affinity |
| Description: |
Although TRPC3, Cardiac-specific overexpression of the protein in transgenic mice resulted in heightened sensitivity to stress, Immunofluorescence studies showed that most TRPC6 expression is confined to podocytes, It is also expressed in glomerular endothelial cells, Northern blot analysis revealed that TRPC6 is expressed primarily in placenta, Studies of Trpc6 -/- mice showed that it has a role in regulation of smooth muscle tone in blood vessels and lung, The protein is a nonselective cation channel that is activated by diacylglycerol (DAG) in a membrane-delimited fashion, a marker for pathologic hypertrophy, a propensity for lethal cardiac growth and heart failure, also known as TRP6, and an increase in Nfat-dependent expression of beta-myosin heavy chain(MYH7), and small intestine, human TRPC1 and mouse Trpc4 and Trpc5 were unresponsive to DAG, independently of protein kinase C, is a transient receptor potentialion channel, is activated in the same manner, lung, member 6, ovary, spleen, subfamily C, the closest structural relative of TRPC6, Transient receptor potential cation channel |
| Immunogen: |
An amino acid sequence from the middle region of human TRPC6 (HDYFCKCNDCNQKQKHD) was used as the immunogen for this TRPC6 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TRPC6 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TRPC6 |
| Short name: |
TRPC6 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TRPC6 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12338 |
| Gene: |
TRPC6 |
More about : TRPC6 |
| Long gene name: |
transient receptor potential cation channel subfamily C member 6 |
| Synonyms gene: |
FSGS2 |
| Synonyms gene name: |
focal segmental glomerulosclerosis 2 transient receptor potential cation channel, member 6 , subfamily C |
| Synonyms: |
TRP6 |
| Locus: |
11q22, 1 |
| Discovery year: |
1998-08-05 |
| GenBank acession: |
AJ006276 |
| Entrez gene record: |
7225 |
| Pubmed identfication: |
9925922 16382100 15879175 |
| RefSeq identity: |
NM_004621 |
| Classification: |
Transient receptor potential cation channels |
| Havana BLAST/BLAT: |
OTTHUMG00000167483 |