| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CYP11A1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the CYP11A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CYP11A1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9QZ82 |
| Purity: |
Antigen affinity |
| Description: |
20-hydroxyvitamin D3 and 20, 22-dihydroxyvitamin D3, CYP11A1 catalyzed the metabolism of biologically inert vitamin D3, CYP11A1 catalyzed the side-chain cleavage of 7-dehydrocholesterol to form 7-dehydropregnenolone, CYP11A1 is a member of the cytochrome P450 superfamily of enzymes, Expression of the CYP11A1 gene may play a role in skin physiology and pathology and that cutaneous proopiomelanocortin activity may be autoregulated by a feedback mechanism involving glucocorticoids synthesized locally by Slominski et al, In addition, Mutations in the CYP11A1 gene cause congenital adrenal insufficiency with partial or complete 46, P450C11A1 or CYP11A, The CYP11A1 gene is mapped on 15q24, Using in vitro studies, XY sex reversal, also called P450SCC, family 11, is a mitochondrial enzyme associated with the conversion of cholesterol to pregnenolone, polypeptide 1, subfamily A, to form 2 hydroxylated products, which is formed from 7-dehydrocholesterol, 1, Cytochrome p450 |
| Immunogen: |
An amino acid sequence from the N-terminus of mouse CYP11A1 (DNGWLNLYHFWRES) was used as the immunogen for this CYP11A1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CYP11A1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CYP11A1 |
| Short name: |
CYP11A1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CYP11A1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2590 |
| Gene: |
CYP11A1 |
More about : CYP11A1 |
| Long gene name: |
cytochrome P450 family 11 subfamily A member 1 |
| Synonyms gene: |
CYP11A |
| Synonyms gene name: |
cytochrome P450, family 11, polypeptide 1 , subfamily A, subfamily XIA (cholesterol side chain cleavage) cytochrome P450 |
| Synonyms: |
P450SCC |
| Synonyms name: |
cholesterol monooxygenase (side-chain-cleaving) |
| Locus: |
15q24, 1 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AK056794 |
| Entrez gene record: |
1583 |
| Classification: |
Cytochrome P450 family 11 |
| Havana BLAST/BLAT: |
OTTHUMG00000150716 |