| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
NOX1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the NOX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This NOX1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9WV87 |
| Purity: |
Antigen affinity |
| Description: |
50% survival rates were enhanced significantly more by Nox2 deletion than Nox1 deletion, Cells expressing NOX1 had a transformed appearance, Disruption of either Nox1 or Nox2 significantly delayed progression of motor neuron disease in these mice, However, It is also a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, It is expressed in colon, MOX1 or GP91-2, Overexpression of NOX1 in NIH3T3 cells increased superoxide generation and cell growth, The deduced 564-amino acid NOX1 protein, also known as NOH1, and histidines possibly involved in heme ligation, and produced tumors in athymic mice, and vascular smooth muscle, but not in peripheral blood leukocytes, conserved flavin and pyridine nucleotide-binding sites, contains 6 membrane-spanning regions, gp91phox, is an enzyme that in humans is encoded by the NOX1 gene, prostate, showed anchorage-independent growth, uterus, which is 58% identical to CYBB, NADPH OXIDASE 1 |
| Immunogen: |
An amino acid sequence from the middle region of rat NOX1 (WYKFQRAHNKLKTQK) was used as the immunogen for this NOX1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the NOX1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
NOX1 |
| Short name: |
NOX1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NADPH oxidase 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, NADP binding, NOX1 and IDBG-633329 and ENSBTAG00000016761 and 521681, NOX1 and IDBG-79287 and ENSG00000007952 and 27035, Nox1 and IDBG-170699 and ENSMUSG00000031257 and 237038, this GO :0001525 and angiogenesis and biological process this GO :0003081 and regulation of systemic arterial blood pressure by renin-angiotensin and biological process this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005768 and endosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0006739 and NADP metabolic process and biological process this GO :0006801 and superoxide metabolic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0007165 and signal transduction and biological process this GO :0008217 and regulation of blood pressure and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0010575 and positive regulation vascular endothelial growth factor production and biological process this GO :0015992 and proton transport and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016175 and superoxide-generating NADPH oxidase activity and molecular function this GO :0016477 and cell migration and biological process this GO :0016491 and oxidoreductase activity and molecular function this GO :0030054 and cell junction and cellular component this GO :0030171 and voltage-gated proton channel activity and molecular function this GO :0030198 and extracellular matrix organization and biological process this GO :0034765 and regulation of ion transmembrane transport and biological process this GO :0042554 and superoxide anion generation and biological process this GO :0042743 and hydrogen peroxide metabolic process and biological process this GO :0043020 and NADPH oxidase complex and cellular component this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0045087 and innate immune response and biological process this GO :0045726 and positive regulation of integrin biosynthetic process and biological process this GO :0045730 and respiratory burst and biological process this GO :0046330 and positive regulation of JNK cascade and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048365 and Rac GTPase binding and molecular function this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0050661 and NADP binding and molecular function this GO :0051454 and intracellular pH elevation and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0071438 and invadopodium membrane and cellular component this GO :0071455 and cellular response to hyperoxia and biological process this GO :0071468 and cellular response to acidity and biological process this GO :0072592 and oxygen metabolic process and biological process this GO :1902177 and positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0016175 : superoxide-generating NADPH oxidase activity and also this GO :0016491 : oxidoreductase activity and also this GO :0030171 : voltage-gated proton channel activity and also this GO :0046872 : metal ion binding and also this GO :0048365 : Rac GTPase binding and also this GO :0050661 : NADP binding, this GO :0016175 : superoxide-generating NADPH oxidase activity, this GO :0016491 : oxidoreductase activity, this GO :0030171 : voltage-gated proton channel activity, this GO :0046872 : metal ion binding, this GO :0048365 : Rac GTPase binding, this GO :0050661 : NADP binding, NADPH oxidase 1 |
| Identity: |
7889 |
| Gene: |
NOX1 |
More about : NOX1 |
| Long gene name: |
NADPH oxidase 1 |
| Synonyms: |
NOH1 NOH-1 MOX1 GP91-2 |
| Synonyms name: |
mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating) NADPH oxidase homolog-1 NADPH oxidase 1 variant NOH-1L |
| Locus: |
Xq22, 1 |
| Discovery year: |
2000-03-24 |
| GenBank acession: |
AF127763 |
| Entrez gene record: |
27035 |
| Pubmed identfication: |
10485709 10615049 |
| RefSeq identity: |
NM_007052 |
| Havana BLAST/BLAT: |
OTTHUMG00000022007 |
| Locus Specific Databases: |
Mental Retardation database |