| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HSD17B2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the HSD17B2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This HSD17B2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P51658 |
| Purity: |
Antigen affinity |
| Description: |
And it activity distinguishing between disease-free and diseased endometria, HSD17B2 mRNA was detected in 18 of 42 (43%) adenomas but not in prolactinomas, In the human endometrium, It efficiently catalyzes the oxidative metabolism of androgens and estrogens, The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium, The type 2 enzyme is capable of catalyzing the interconversion of testosterone and androstenedione, a predicted molecular weight of 42, also called 17-beta-HSD II, and associate with the membranes of the endoplasmic reticulum, and it is expressed in a large series of human peripheral tissues, as well as estradiol and estrone, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2, is an enzyme with 387 amino acids, 782D, HSD17B2(17-beta-hydroxysteroid dehydrogenase II) |
| Immunogen: |
An amino acid sequence from the C-terminus of mouse HSD17B2 (QDIWDKMEKEILDHFSK) was used as the immunogen for this HSD17B2 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the HSD17B2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HSD17B2 |
| Short name: |
HSD17B2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HSD17B2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5211 |
| Gene: |
HSD17B2 |
More about : HSD17B2 |
| Long gene name: |
hydroxysteroid 17-beta dehydrogenase 2 |
| Synonyms gene name: |
hydroxysteroid (17-beta) dehydrogenase 2 |
| Synonyms: |
HSD17 SDR9C2 |
| Synonyms name: |
member 2 , short chain dehydrogenase/reductase family 9C |
| Locus: |
16q23, 3 |
| Discovery year: |
1994-09-14 |
| Entrez gene record: |
3294 |
| Pubmed identfication: |
7759109 19027726 |
| RefSeq identity: |
NM_002153 |
| Classification: |
Short chain dehydrogenase/reductase superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000137631 |