| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
GBP1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the GBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This GBP1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P32455 |
| Purity: |
Antigen affinity |
| Description: |
All GBPs have a conserved N-terminal globular GTP-binding domain containing two consensus sequences and a third T(L/V)RD sequence not found in other GTPases, GBP2, GBPs, GDP, High expression of GBP1, It is located telomeric to GBP2 and centromeric to GBP3, TNF, The 593-amino acid GBP1 protein shares 77% and 88% identity with GBP2 and GBP3, The GBP1 gene localizes to the GBP gene cluster on chromosome 1p22, and GBP3 are in endothelial cells after stimulation with IFNG, and GTP) and are distinguished from the GTP-binding proteins by the presence of two binding motifs rather than three, are characterized by their ability to specifically bind guanine nucleotides (GMP, including those coding for guanylate-binding proteins (GBPs), or IL1B, respectively, such as GBP1, 2, Interferons induce a large number of genes in their target cells |
| Immunogen: |
Amino acids 566-589 (QKESRIMKNEIQDLQTKMRRRKAC-human) were used as the immunogen for this GBP1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the GBP1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
GBP1 |
| Short name: |
GBP1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
interferon-inducible (Antibody to), guanylate binding protein 1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, GBP1 and IDBG-100165 and ENSG00000117228 and 2633, identical protein binding, interferon-inducible, this GO :0000139 and this GO lgi membrane and cellular component this GO :0003924 and GTPase activity and molecular function this GO :0005525 and GTP binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005829 and cytosol and cellular component this GO :0006184 and GTP catabolic process and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0042802 and identical protein binding and molecular function this GO :0051607 and defense response to virus and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process, this GO :0003924 : GTPase activity, this GO :0003924 : GTPase activity and also this GO :0005525 : GTP binding and also this GO :0042802 : identical protein binding, this GO :0005525 : GTP binding, this GO :0042802 : identical protein binding, guanylate binding protein 1 |
| Identity: |
4182 |
| Gene: |
GBP1 |
More about : GBP1 |
| Long gene name: |
guanylate binding protein 1 |
| Synonyms gene name: |
67kDa guanylate binding protein 1, guanylate binding protein 1, interferon-inducible, interferon-inducible |
| Locus: |
1p22, 2 |
| Discovery year: |
1995-01-03 |
| GenBank acession: |
BC002666 |
| Entrez gene record: |
2633 |
| Pubmed identfication: |
7518790 |
| RefSeq identity: |
NM_002053 |
| Havana BLAST/BLAT: |
OTTHUMG00000010614 |